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首页> 外文期刊>Cell and Tissue Research >Colonic mesenchyme differentiates into smooth muscle before its colonization by vagal enteric neural crest-derived cells in the chick embryo
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Colonic mesenchyme differentiates into smooth muscle before its colonization by vagal enteric neural crest-derived cells in the chick embryo

机译：结肠间充质细胞分化为在鸡胚中的阴道内肠道神经嵴衍生细胞殖民化之前的平滑肌

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摘要

During development, the gastrointestinal (GI) tract arises from a primary tube composed of mesoderm and endoderm. The mesoderm gives rise to the digestive mesenchyme, which in turn differentiates into multiple tissues, namely the submucosa, the interstitial cells of Cajal and the smooth muscle cells (SMCs). Concomitant with these early patterning events, the primitive GI tract is colonized by vagal enteric neural crest-derived cells (vENCDCs), a population of cells that gives rise to the enteric nervous system, the intrinsic innervation of the GI tract. Reciprocal neuro-mesenchymal interactions are essential for the coordinated development of GI musculature. The aim of this study is to examine and compare the kinetics of mesenchymal cell differentiation into SMCs along the anterior-posterior axis to the pattern of vENCDCs migration using whole-mount in situ hybridization and paraffin section immunofluorescence analyses on chick embryonic GI tracts from E4-Stage 23 to E7-Stages 30-31. We confirmed that gastric and pre-umbilical intestine mesenchyme differentiation into SMCs occurs after vENCDCs colonization. However, we found that colonic and post-umbilical intestine mesenchyme differentiation occurs before vENCDCs colonization. These findings suggest that regional-specific mechanisms are involved in the mesenchyme differentiation into SMCs along the GI anterior-posterior axis.
机译：在开发期间，胃肠道（GI）散发出由由中胚层和内胚层组成的初级管。中胚层产生消化间充质，其又为多种组织区分，即粘膜下沉，Cajal的间质细胞和平滑肌细胞（SMC）。伴随着这些早期的图案化事件，原始的GI道被迷入神经嵴衍生的细胞（Vencdcs）殖民，一种细胞群，导致肠道神经系统，胃肠道的内在内在支配。相互作用的神经间充质相互作用对于Gi Musculature的协调发展是必不可少的。本研究的目的是检查和比较间充质细胞分化的动力学沿着前后轴线的SMC，以使用整体安装在原位杂交和石蜡截面免疫荧光分析来自E4-阶段23至E7-阶段30-31。我们证实，在VencDCS定植后，胃癌和脐肠间充质分化进入SMC。然而，我们发现在Vencdcs定植之前发生结肠和后脐部的间充质分化。这些发现表明，区域特异性机制涉及间充质的分化沿着GI前后轴线的SMC。

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