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首页> 外文期刊>Cell and Tissue Research >Age-dependent decrease in glomeruli and receptor cells containing alpha 1-2 fucose glycan in the mouse main olfactory system but not in the vomeronasal system
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Age-dependent decrease in glomeruli and receptor cells containing alpha 1-2 fucose glycan in the mouse main olfactory system but not in the vomeronasal system

机译：在小鼠主要嗅觉系统中含有α1-2岩藻糖甘油的肾小球和受体细胞的年龄依赖性降低，但不在氟混合物系统中

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摘要

Receptor cells of the olfactory epithelium (OE) and vomeronasal organ (VNO) project axons to glomeruli in the main olfactory bulb (MOB) and accessory olfactory bulb (AOB), respectively and undergo continuous turnover throughout life. Alpha1-2 fucose (alpha 1-2Fuc) glycan mediates neurite outgrowth and synaptic plasticity and plays important roles in the formation of the olfactory system during development. We previously confirmed the localization of alpha 1-2Fuc glycan in the olfactory system of 3- to 4-month-old mice but whether such localization persists throughout life remains unknown. Here, the MOB, AOB, OE and VNO of 1-, 3- and 8-month-old mice were histochemically examined using Ulex europaeus agglutinin-I (UEA-I) that specifically binds to alpha 1-2Fuc glycan. Binding sites for UEA-I in the MOB were similar among all age groups but the ratio of UEA-I-positive glomeruli significantly decreased with aging. The frequency of UEA-I-positive receptor cells in the OE of the two older groups was also significantly lower than that of 1-month-old mice. On the other hand, UEA-I binding in the AOB and VNO did not significantly differ among all three groups. These findings suggest that the primary pathway of the main olfactory system requires the role of alpha 1-2Fuc glycan in young mice rather than old mice, while the vomeronasal pathway equally requires this glycan in both young and old mice.
机译：嗅性上皮（OE）和茂物组织（VOMEronalaal Organ（VNO）的受体细胞分别在主要嗅灯泡（暴徒）和辅助嗅球（AOB）中的肾小球项目轴突，并在整个寿命中经历连续的周转。 α1-2岩藻糖（Alpha 1-2Fuc）Glycan介断了神经突的出现和突触可塑性，并在开发过程中形成了嗅觉系统的重要作用。我们以前证实了3至4个月大的老鼠的嗅觉系统中Alpha 1-2Fuc Glycan的定位，但在整个生命中是否持续存在。这里，1-，3-和8个月大鼠的暴徒，AOB，OE和VNO通过特异性结合α1-2Fuc聚糖的Ulex Europaeus aglutinin-I（UEA-I）组织化学检查。所有年龄组的UEA-I的结合位点在所有年龄组中相似，但UEA-I阳性肾小球的比例随着衰老的显着降低。两个较旧的群体OE中的UEA-I阳性受体细胞的频率也明显低于1个月大鼠的小鼠。另一方面，在AOB和VNO中的UEA-I结合在所有三个群体中没有显着不同。这些研究结果表明，主要嗅觉系统的主要途径需要α1-2Fuc甘草在年轻小鼠而不是旧小鼠中的作用，而莫柳菌途径同样需要这种糖粉在年轻和老年小鼠中。

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