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首页> 外文期刊>Cellular immunology >An autoantibody against a 48-Kd fragment of human DNA-topoiomerase I in breast cancer: Implication for diagnosis and prognosis, and antibody-dependent cellular cytotoxicity in vitro
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An autoantibody against a 48-Kd fragment of human DNA-topoiomerase I in breast cancer: Implication for diagnosis and prognosis, and antibody-dependent cellular cytotoxicity in vitro

机译：对乳腺癌中48kd片段的48kd片段的自身抗体：对诊断和预后的影响，以及体外抗体依赖性细胞细胞毒性

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摘要

Previously, we reported a novel tumor-associated antigen (FAA) derived from human DNA-topoiomerase I (TOP 1). In the present study, we demonstrated that the autoantibody against the TAA could be a potential biomarker in the early diagnosis and favorable prognosis of patients with breast cancer (BC). To understand the survival benefits in BC patients, we investigated whether the autoantibody could induce antibody-dependent cellular cytotoxicity activities (ADCC) against breast cancer cells in vitro. We found that the autoantibody exhibited significant ADCC activities that destroyed breast cancer MCF-7 and MDA-MB-231 cells with peripheral blood mononuclear cells (PBMCs). The ADCC activities of the autoantibody were significantly correlated with the number of natural killer (NK) cells, NKT cells, and CD4(+)/CD8(+) T cells. Accordingly, our findings showed that the autoantibody not only represented an early index of immune response to the TAA, but also was involved in host immune defense mechanisms that initiated the destruction of cancer cells.
机译：以前，我们报道了一种新的肿瘤相关抗原（FAA）衍生自人DNA- TOPOIOO聚物酶I（前1个）。在本研究中，我们证明，对TAA的自身抗体可能是患有乳腺癌（BC）患者的早期诊断和有利预后的潜在生物标志物。为了了解BC患者的生存益处，我们研究了自身抗体是否可以在体外诱导抗体依赖性细胞细胞毒性（ADCC）对乳腺癌细胞。我们发现，自身抗体表现出显着的ADCC活性，可破坏乳腺癌MCF-7和MDA-MB-231细胞，外周血单核细胞（PBMC）。自身抗体的ADCC活性与天然杀伤剂（NK）细胞，NKT细胞和CD4（+）/ CD8（+）T细胞显着相关。因此，我们的研究结果表明，自身抗体不仅代表了对TAA的免疫应答的早期指标，而且还参与了启动癌细胞破坏的宿主免疫防御机制。

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