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首页> 外文期刊>Cellular immunology >Co-appearance of autoantibody-producing B220(low) B cells with NKT cells in the course of hepatic injury.
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Co-appearance of autoantibody-producing B220(low) B cells with NKT cells in the course of hepatic injury.

机译：肝损伤过程中具有NKT细胞的自身抗体产生B220（低）B细胞的外观。

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摘要

Severe hepatic injury is induced by Concanavalin A (Con A) administration in mice, the major effector cells being CD4(+) T cells, NKT cells and macrophages. Since autologous lymphocyte subsets are associated with tissue damage, Con A-induced hepatic injury is considered to be autoimmune hepatitis. However, it has remained to be investigated how autoantibodies and B-1 cells are responsible for this phenomenon. In this study, it was demonstrated that autoantibodies which were detected using Hep-2 cells in immunofluorescence tests and using double-strand (ds) DNA in the ELISA method, appeared after Con A administration (a peak at day 14). Moreover, autoantibody-producing B220(low) cells (i.e., B-1 cells) also appeared at this time. Purified B220(low) cells were found to have a potential to produce autoantibodies. These results suggest that Con A-induced hepatic injury indeed includes the mechanism of autoimmune hepatitis.
机译：在小鼠中康丹韦A（CON A）给药诱导严重的肝损伤，主要效应细胞是CD4（+）T细胞，NKT细胞和巨噬细胞。 由于自体淋巴细胞子集与组织损伤有关，因此Con诱导的肝损伤被认为是自身免疫性肝炎。 然而，仍然需要研究自身抗体和B-1细胞如何对这种现象负责。 在本研究中，证明了在CON施用（第14天的峰值）之后，在ELISA方法中使用HEP-2细胞检测到使用Hep-2细胞检测的自身抗体。 此外，此时也出现了产生自身抗体的B220（低）细胞（即，B-1细胞）。 发现纯化的B220（低）细胞具有产生自身抗体的潜力。 这些结果表明，CON诱导的肝损伤确实包括自身免疫性肝炎的机制。

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