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首页> 外文期刊>Cellular immunology >Identification and characterization of autoantibody-producing B220(low) B (B-1) cells appearing in malarial infection.
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Identification and characterization of autoantibody-producing B220(low) B (B-1) cells appearing in malarial infection.

机译：鉴定和表征在疟疾感染中出现的产生自身抗体的B220（low）B（B-1）细胞。

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摘要

Mice with malaria showed unique immunological responses, including the expansion of NK1.1(-)TCR(int) cells (extrathymic T cells). Since TCR(int) cells with autoreactivity and autoantibody-producing B cells (B-1 cells) are often simultaneously activated under autoimmune conditions, it was examined whether B-1 cells were activated in the course of malarial infection. From days 14 after infection, B220(low) B-1 cells appeared in the liver and spleen. The number of B220(low) B cells was highest at day 14, but the ratio was highest at days 28-35. In parallel with the appearance of B220(low) cells, autoantibodies against HEp-2 cells and double-stranded DNA were detected in sera. These B220(low) cells had phenotypes of CD44(high), CD23(-) and CD62L(-). In sharp contrast, conventional B220(high) B cells (B-2 cells) were CD44(low), CD23(+) and CD62L(+). These results suggested that malaria immune responses were not mediated by conventional T and B cells but resembled the responses during autoimmune diseases.
机译：疟疾小鼠表现出独特的免疫反应，包括NK1.1（-）TCR（int）细胞（胸腺T细胞）的扩增。由于具有自身反应性的TCR（int）细胞和产生自身抗体的B细胞（B-1细胞）通常在自身免疫条件下被同时激活，因此检查了在疟疾感染过程中B-1细胞是否被激活。从感染后第14天起，肝和脾中出现B220（low）B-1细胞。 B220（低）B细胞的数量在第14天最高，但比率在28-35天最高。与B220（low）细胞的出现并行，在血清中检测到针对HEp-2细胞和双链DNA的自身抗体。这些B220（低）细胞具有CD44（高），CD23（-）和CD62L（-）的表型。与之形成鲜明对比的是，常规的B220（高）B细胞（B-2细胞）为CD44（低），CD23（+）和CD62L（+）。这些结果表明，疟疾的免疫反应不是由常规的T细胞和B细胞介导的，而是类似于自身免疫疾病中的反应。

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