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首页> 外文期刊>Cellular immunology >The contribution of immune infiltrates and the local microenvironment in the pathogenesis of osteosarcoma
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The contribution of immune infiltrates and the local microenvironment in the pathogenesis of osteosarcoma

机译：免疫浸润和局部微环境在骨肉瘤发病机制中的贡献

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摘要

Osteosarcoma is a rare primary bone cancer characterized by cancer cells producing calcified osteoid extracellular matrix and inducing lung metastases with a high frequency. The local microenvironment defined several tumor niches controlling the tumor growth and cell extravasation. The immune infiltrate composes one of these niches. The immune environment of osteosarcoma is mainly composed by T-lymphocytes and macrophages but also contains other subpopulations including B-lymphocytes and mast cells. Osteosarcoma cells control the recruitment and differentiation of immune infiltrating cells and establish a local immune tolerant environment favorable to the tumor growth, drug resistance and the occurrence of metastases. Osteosarcoma cells are able to affect the balance between M1 and M2 macrophage subtypes and so could control the T-lymphocyte responses via the PD-1/PDL-1 system. In addition, mesenchymal stem cells may also contribute to this immune tolerance and strengthen the immune evasion. The present review gives a brief overview of the immune components of osteosarcoma and their most recent therapeutic interests.
机译：骨肉瘤是一种罕见的原发性骨癌，其特征在于产生钙质细胞，产生钙化骨质细胞外基质和具有高频率的肺转移。局部微环境定义了一种控制肿瘤生长和细胞外渗的几种肿瘤核心。免疫渗透组成了其中一个利基。 Osteosarcoma的免疫环境主要由T淋巴细胞和巨噬细胞组成，但还含有其他亚群，包括B淋巴细胞和肥大细胞。骨肉瘤细胞控制免疫渗透细胞的募集和分化，并建立局部免疫耐受环境，良好于肿瘤生长，耐药性和转移的发生。骨肉瘤细胞能够影响M1和M2巨噬细胞亚型之间的平衡，因此可以通过PD-1 / PDL-1系统控制T淋巴细胞反应。此外，间充质干细胞也可能有助于这种免疫耐受性，并加强免疫逃避。本综述简要概述了骨肉瘤的免疫成分及其最近的治疗兴趣。

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