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首页> 外文期刊>Cell cycle >MAFG-AS1 is a novel clinical biomarker for clinical progression and unfavorable prognosis in gastric cancer
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MAFG-AS1 is a novel clinical biomarker for clinical progression and unfavorable prognosis in gastric cancer

机译：MAFG-AS1是一种新型临床生物标志物，可用于胃癌临床进展和不利预后

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摘要

MAFG antisense 1 (MAFG-AS1) is recently identified as a novel lncRNA and serves as a tumor promoter in several types of human tumor. However, no prior study has been performed to evaluate the role of MAFG-AS1 in gastric cancer. In our study, we found MAFG-AS1 expression was increased in gastric cancer tissue samples compared with normal gastric mucosa tissue samples, and associated with poor overall survival in gastric cancer patients at The Cancer Genome Atlas database. Furthermore, we confirmed the clinical and prognostic significance of MAFG-AS1 in gastric cancer. We found gastric cancer tissues and cell lines had remarkably increased MAFG-AS1 expression in comparison to normal gastric mucosa tissues and normal human gastric epithelial cell line, and high MAFG-AS1 expression was positively associated with diffuse type, advanced clinical stage, extensive depth of invasion, more lymph node metastasis, and present distant metastasis in gastric cancer patients. Moreover, high MAFG-AS1 expression acted as one of the independent poor prognostic factors for overall survival in gastric cancer patients. The loss-of-function study showed knocking down MAFG-AS1 expression inhibited gastric cancer cell proliferation, migration and invasion in vitro. In conclusion, MAFG-AS1 is probable to be a valuable prognostic biomarker, and a novel potential target for gastric cancer.
机译：最近将MAFG反义1（MAFG-AS1）鉴定为新型LNCRNA，并用作几种类型的人肿瘤中的肿瘤启动子。然而，未进行现有研究以评估MAFG-AS1在胃癌中的作用。在我们的研究中，我们发现MAFG-AS1表达在胃癌组织样品中增加了与正常胃黏膜组织样本相比，并且在癌症基因组数据库中胃癌患者的整体存活差。此外，我们证实了MAFG-AS1在胃癌中的临床和预后意义。我们发现胃癌组织和细胞系具有显着增加的MAFG-AS1表达与正常胃粘膜组织和正常人胃上皮细胞系相比，高MAFG-AS1表达与弥漫性型，高级临床阶段，广泛的深度呈正相关侵袭，更多淋巴结转移，并在胃癌患者中存在远端转移。此外，高MAFG-AS1表达作用为胃癌患者整体存活的独立差的预后因素之一。功能丧失的研究表明，爆震MAFG-AS1表达抑制胃癌细胞增殖，迁移和侵袭体外。总之，MAFG-AS1可能是一种有价值的预后生物标志物，以及胃癌的新潜在靶标。

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