Contribution to neural and mesodermal lineages by porcine skin-derived progenitors (SKPs) in vivo.

Zhao MT; Zhang X; Whitworth KM; Rieke A; Prather RS

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Contribution to neural and mesodermal lineages by porcine skin-derived progenitors (SKPs) in vivo.

机译：通过体内猪皮肤衍生的祖细胞（SKP）对神经和中胚层谱系的贡献。

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Multipotent skin-derived progenitors (SKPs) are neural crest derived and can be isolated from both embryonic and adult skin in humans, rodents and pigs. The SKPs are capable of generating both neural and mesodermal progeny in vitro: neurons, Schwann cells, adipocytes, osteo-cytes, and chondrocytes, thus exhibiting properties similar to embryonic neural crest stem cells. However, SKPs show distinct transcriptional profiles when compared to neural stem cells in the central nervous system and skin derived fibroblast, indicating a novel type of multipotent stem cells derived from skin. The SKPs are derived from hair follicle progenitors and exhibit adult dermal stem cell properties, contributing to dermal maintenance, wound-healing, and hair follicle morphogenesis.

机译：多能皮肤衍生的祖细胞（SKP）是神经嵴衍生，可以从人类，啮齿动物和猪中的胚胎和成人皮肤中分离出来。 SKP能够在体外产生神经和中胚层后代：神经元，施曼细胞，脂肪细胞，骨质细胞和软骨细胞，因此表现出类似于胚胎神经嵴干细胞的性质。然而，与中枢神经系统和皮肤衍生成纤维细胞中的神经干细胞相比，SKP显示出不同的转录型材，表明衍生自皮肤的新型多电干细胞。 SKP源自毛囊祖细胞，表现出成年皮肤干细胞性质，有助于皮肤维持，伤口愈合和毛发卵泡形态发生。

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《Cell cycle》 |2010年第10期|共2页
作者
Zhao MT; Zhang X; Whitworth KM; Rieke A; Prather RS;
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作者单位

Division of Animal Sciences University of Missouri Columbia MO USA;

Institute of Biotechnology Northwest A&

F University Yangling Shaanxi China.;

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正文语种 eng
中图分类细胞生物学;
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1. Contribution to neural and mesodermal lineages by porcine skin-derived progenitors (SKPs) in vivo. [J] . Zhao MT, Zhang X, Whitworth KM, Cell cycle . 2010,第10期

机译：通过体内猪皮肤衍生的祖细胞（SKP）对神经和中胚层谱系的贡献。
2. Porcine Skin-Derived Progenitor (SKP) Spheres and Neurospheres: Distinct "Stemness" Identified by Microarray Analysis [J] . Zhao Ming-Tao, Whitworth Kristin M., Lin Hui, Cellular reprogramming . 2010,第3期

机译：猪皮肤来源祖细胞（SKP）球和神经球：通过微阵列分析鉴定的不同“茎干”
3. The potential of mouse skin-derived precursors to differentiate into mesenchymal and neural lineages and their application to osteogenic induction in vivo. [J] . Kang HK, Min SK, Jung SY, International journal of molecular medicine . 2011,第6期

机译：小鼠皮肤来源的前体分化为间充质和神经谱系的潜力及其在体内成骨诱导中的应用。
4. The Use of Fetal Progenitor Cells of Neural Lineage for the Regeneration of the Peripheral Nerves Inside Tabular Prostheses: An Experimental Study In Rats [C] . F.I. Souza, A.V. Zumiotti, C.F. Silva, World Society for Reconstructive Microsurgery . 2005

机译：神经谱系的使用胎儿祖细胞进行表格假体内外周神经的再生：大鼠的实验研究
5. Periodontal Regeneration by Allogeneic Transplantation of Adipose-tissue Derived Multi-Lineage Progenitor Stem Cells in vivo. [D] . VENKATAIAH VENKATA SURESH 2019

机译：通过异体移植体内脂肪组织的多谱系祖细胞进行牙周再生。
6. Contribution to neural and mesodermal lineages by porcine skin-derived progenitors (SKPs) in vivo [O] . Ming-Tao Zhao, Martha W. Bennett, Xia Zhang, -1

机译：通过猪皮肤衍生的祖细胞（SKP）在体内对神经和中胚层谱系的贡献
7. Deciphering the Mesodermal Potency of Porcine Skin-Derived Progenitors (SKP) by Microarray Analysis [O] . Zhao, Ming-Tao, Whitworth, Kristin M., Zhang, Xia, 2010

机译：通过芯片分析破译猪皮肤来源祖细胞（SKP）的中胚层效能。

Contribution to neural and mesodermal lineages by porcine skin-derived progenitors (SKPs) in vivo.

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