BubR1, a spindle assembly checkpoint protein in mammalian oocyte meiosis.

Fan HY

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BubR1, a spindle assembly checkpoint protein in mammalian oocyte meiosis.

机译：Bubr1，哺乳动物卵母细胞减数分裂中的主轴组件检查点蛋白。

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During eukaryote mitosis, spindle assembly checkpoint (SAC) is a ubiquitous surveillance mechanism to ensure genome stability. Through blocking precocious anaphase onset, SAC prevents chromosome mis-segregation and aneuploidy, and its defection is associated with tumorigenesis, early embryo death, spontaneous abortion or genetic diseases. So far, numerous SAC components have been identified in mitosis. Mad1, Mad2, Mad3 (BubR1), Bub1 and Bub3 are regarded as the core components of SAC. Moreover, Mad2, BubR1, Bub3 and CDC20 constitute mitotic checkpoint complex (MCC) which is considered as the direct effector of the SAC pathway. The checkpoint proteins are activated and recruited to specific subcellular positions at prometaphase to avoid precocious separation of sister chro-matids during mitotic metaphase.

机译：在真核细胞源期间，主轴组件检查点（SAC）是一种普遍存在的监测机制，以确保基因组稳定性。通过阻断预先诱导的后源性发作，囊防止染色体的误区和非整倍性，其缺陷与肿瘤发生，早期胚胎死亡，自发性流产或遗传疾病有关。到目前为止，已经在有丝分裂中鉴定了许多囊组分。 Mad1，Mad2，Mad3（Bubr1），Bub1和Bub3被认为是囊的核心组分。此外，MAD2，BUBR1，BUB3和CDC20构成有丝分子检查点复合物（MCC），被认为是囊道途径的直接效应器。检查点蛋白被激活并募集到Prometaphase的特定亚细胞位置，以避免在有丝分裂中期期间的姐妹Chro-Matid的早期分离。

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《Cell cycle》 |2010年第8期|共1页
作者
Fan HY;
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Zhejiang University Hangzhou China.;

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正文语种 eng
中图分类细胞生物学;
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1. BubR1, a spindle assembly checkpoint protein in mammalian oocyte meiosis. [J] . Fan HY Cell cycle . 2010,第8期

机译：Bubr1，哺乳动物卵母细胞减数分裂中的主轴组件检查点蛋白。
2. BubR1 is a spindle assembly checkpoint protein regulating meiotic cell cycle progression of mouse oocyte. [J] . Sun QY Cell cycle . 2010,第6期

机译：BubR1是纺锤体装配检查点蛋白，可调节小鼠卵母细胞的减数分裂细胞周期进程。
3. BubR1 is a spindle assembly checkpoint protein regulating meiotic cell cycle progression of mouse oocyte. [J] . Sun QY Cell cycle . 2010,第6期

机译：BUBR1是梭形组件检查点蛋白调节小鼠卵母细胞的减数分裂细胞周期进展。
4. Understanding How Taxol Re-Imposes the Spindle Assembly Checkpoint Using Correlative Microscopy [C] . Jeffrey G. Ault, Valentin Magidson, Alexey Khodjakov Microscopy Society of America Annual Meeting;Microanalysis Society Annual meeting;International Metallographic Society Annual meeting . 2012

机译：使用相关显微镜了解紫杉醇如何重新施加主轴组件检查点
5. The Arabidopsis nucleoporin NUA is involved in mRNA export and functionally interacts with spindle assembly checkpoint proteins. [D] . Muthuswamy, Sivaramakrishnan. 2010

机译：拟南芥核孔蛋白NUA参与mRNA的输出，并与纺锤体装配检查点蛋白发生功能性相互作用。
6. Protein Interaction Domain Mapping of Human Kinetochore Protein Blinkin Reveals a Consensus Motif for Binding of Spindle Assembly Checkpoint Proteins Bub1 and BubR1 [O] . Tomomi Kiyomitsu, Hiroaki Murakami, Mitsuhiro Yanagida 2011

机译：人动线蛋白Blinkin的蛋白质相互作用域映射揭示了主轴组装检查点蛋白Bub1和BubR1结合的共识母题。
7. Bub3 is a spindle assembly checkpoint protein regulating chromosome segregation during mouse oocyte meiosis. [O] . Mo Li, Sen Li, Ju Yuan, 2009

机译：Bub3是在小鼠卵母细胞减数分裂过程中调节染色体分离的纺锤体组装检查点蛋白。

BubR1, a spindle assembly checkpoint protein in mammalian oocyte meiosis.

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