The frequency of homologous recombination in human ALT cells.

Bechter OE; Shay JW; Wright WE

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The frequency of homologous recombination in human ALT cells.

机译：人ALT细胞中同源重组的频率。

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Instead of telomerase, some immortal cells use the alternative lengthening of telomeres pathway (ALT) to maintain their telomeres. There is good evidence that homologous recombination contributes to the ALT mechanism. Using an inducible GFP reporter system to measure the frequency of homologous recombination, we asked whether or not ALT cells exhibited a general change of the recombination machinery. Our results show that the frequency of homologous recombination for non-telomeric sequences in ALT cells is identical to that in telomerase positive cells, irrespective of whether the reporter was present at an intra-chromosomal location or next to a telomeric sequence. We conclude that the underlying recombination defect in ALT cells is restricted to telomeric sequences.

机译：一些不朽的细胞而不是端粒酶，使用端粒途径（ALT）的替代延长来维持其端粒。有良好的证据表明同源重组有助于ALT机制。使用诱导GFP报告系统测量同源重组的频率，我们询问ALT细胞是否表现出重组机械的一般变化。我们的结果表明，ALT细胞中非极端序列的同源重组的频率与端粒酶阳性细胞中的相同，而不管报道者是否存在于染色体内位置或旁边的端粒序列。我们得出结论，ALT细胞中的潜在的重组缺陷仅限于端粒序列。

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来源
《Cell cycle》 |2004年第5期|共3页
作者
Bechter OE; Shay JW; Wright WE;
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作者单位

UT Southwestern Medical Center Dallas Texas 75390-9039 USA.;

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原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
Alanine aminotransferase measurement; homologous recombination; With frequency; 端粒; 末端转移酶;

机译：Alanine aminotransferase measurement;homologous recombination;With frequency;端粒;末端转移酶;

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1. The frequency of homologous recombination in human ALT cells. [J] . Bechter OE, Shay JW, Wright WE Cell cycle . 2004,第5期

机译：人ALT细胞中同源重组的频率。
2. Effect of the overexpression of BRCA2 unclassified missense variants on spontaneous homologous recombination in human cells. [J] . Balia C, Galli A, Caligo MA Breast cancer research and treatment. . 2011,第3期

机译：BRCA2未分类的错义变体的过表达对人细胞中自发同源重组的影响。
3. Artificial restriction DNA cutters to promote homologous recombination in human cells. [J] . Katada H, Komiyama M Current gene therapy . 2011,第1期

机译：人工限制性DNA切割剂，可促进人类细胞中的同源重组。
4. TARGETED GENE CORRECTION OF ACTIVATED HUMAN H-RAS GENE BY SMALL FRAGMENT HOMOLOGOUS RECOMBINATION [C] . Hiroyuki Tsuchiya, Hiroyuki Kamiya, Hideyoshi Harashima Proceedings of the 29th Annual Meeting of the Controlled Release Society . 2002

机译：小片段同源重组重组人H-RAS基因的靶向基因校正
5. Double-strand DNA break repair by homologous recombination contributes to the preservation of genomic stability in mouse embryonic stem cells. [D] . Tichy, Elisia D. 2010

机译：通过同源重组的双链DNA断裂修复有助于维持小鼠胚胎干细胞的基因组稳定性。
6. Homologous recombination in human telomerase-positive and ALT cellsoccurs with the same frequency [O] . Oliver E Bechter, Ying Zou, Jerry W Shay, 2003

机译：人端粒酶阳性和ALT细胞中的同源重组以相同的频率发生
7. I-SceI-mediated double-strand break does not increase the frequency of homologous recombination at the Dct locus in mouse embryonic stem cells. : Homologous recombination at the Dct locus [O] . Fenina, Myriam, Simon-Chazottes, Dominique, Vandormael-Pournin, Sandrine, 2012

机译：I-SceI介导的双链断裂不会增加小鼠胚胎干细胞中Dct基因座上同源重组的频率。：在Dct基因座的同源重组

The frequency of homologous recombination in human ALT cells.

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