...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell cycle >The established and the predicted roles of dynein light chain in the regulation of mitochondrial apoptosis
【24h】

The established and the predicted roles of dynein light chain in the regulation of mitochondrial apoptosis

机译：Dynein轻链在线粒体细胞凋亡调节中的已建立和预测的作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The mitochondrial pathway of apoptosis is regulated by the interplay between the members of Bcl-2 family. Within this family, BH3-only proteins are the sensors of apoptotic stimuli and can trigger apoptosis either by inhibiting the anti-apoptotic Bcl-2-family proteins or by directly activating the effectors Bax and Bak. An expanding body of research suggests that a number of non-Bcl-2 proteins can also interact with Bcl-2 proteins and contribute to the decision of cell fate. Dynein light chain (LC8, DYNLL or DLC), a hub protein and a dimerizing engine has been proposed to regulate the pro-apoptotic activity of two BH3-only proteins, Bim and Bmf. Our recent work has provided insight into the mechanisms through which DLC1 (DYNLL1) modulates Bim activity. Here we discuss the present day understanding of Bim-DLC interaction and endeavor to evaluate this interaction in the light of information from studies of DLC with other binding partners.
机译：细胞凋亡的线粒体途径受Bcl-2家族成员之间的相互作用。 在该家庭中，仅限BH3蛋白是凋亡刺激的传感器，可以通过抑制抗凋亡Bcl-2 - 家族蛋白或通过直接激活菌和Bak来引发细胞凋亡。 扩展研究表明，许多非Bcl-2蛋白也可以与Bcl-2蛋白相互作用并有助于细胞命运的决定。 已经提出了Dynein轻链（LC8，DynL1或DLC），轮毂蛋白和二聚化发动机来调节两种BH3蛋白，BIM和BMF的促凋亡活性。 我们最近的工作已经为DLC1（Dynll1）调制了BIM活动的机制提供了深入了解。 在这里，我们讨论了对BIM-DLC互动和努力根据DLC研究与其他结合伴侣的信息来评估这种相互作用的讨论。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号