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首页> 外文期刊>Cell cycle >Regulation of Cenp-F localization to nuclear pores and kinetochores
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Regulation of Cenp-F localization to nuclear pores and kinetochores

机译：将CENP-F定位调节到核毛孔和KINETOCHORE

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摘要

In metazoans, the assembly of kinetochores on centrometric chromatin and the dismantling of nuclear pore complexes are processes that have to be tightly coordinated to ensure the proper assembly of the mitotic spindle and a successful mitosis. It is therefore noteworthy that these two macromolecular assemblies share a subset of constituents. One of these multifaceted components is Cenp-F, a protein implicated in cancer and developmental pathologies. During the cell cycle, Cenp-F localizes in multiple cellular structures including the nuclear envelope in late G2/early prophase and kinetochores throughout mitosis. We recently characterized the molecular determinants of Cenp-F interaction with Nup133, a structural nuclear pore constituent. In parallel with two other independent studies, we further elucidated the mechanisms governing Cenp-F kinetochore recruitment that mainly relies on its interaction with Bub1, with redundant contribution of Cenp-E upon acute microtubule depolymerisation. Here we synthesize the current literature regarding the dual location of Cenp-F at nuclear pores and kinetochores and extend our discussion to the regulation of these NPC and kinetochore localizations by mitotic kinase and spindle microtubules.
机译：在Metazoans中，在中心染色蛋白上的Kinetochores组装和核孔隙络合物的拆卸是必须紧密协调的过程，以确保有丝分裂主轴的适当组装和成功的有丝分裂。因此，这两个大分子组件共享成分的子集。这些多方型组分中的一种是CENP-F，蛋白质涉及癌症和发育病理学。在细胞周期期间，CENP-F在多种细胞结构中定位在包括在G2 /早期预先致作用病的早期预先链胞和Kinetochores的核包膜中的多个蜂窝结构。我们最近表征了CENP-F与NUP133的分子决定因素，结构核孔组成部分。与其他另外两个独立研究平行，我们进一步阐明了CENP-F KINETOCHORE招生的机制，这些机制主要依赖于其与BUB1的相互作用，CENP-E对急性微管解聚的冗余贡献。在这里，我们将目前文献综合了关于CENP-F的核毛孔和Kinetochores的双重位置，并通过有丝分裂激酶和主轴微管对这些NPC和KINETOCHORE局部调节进行讨论。

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