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首页> 外文期刊>Cell cycle >Cdks and cyclins link G(1) length and differentiation of embryonic, neural and hematopoietic stem cells.
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Cdks and cyclins link G(1) length and differentiation of embryonic, neural and hematopoietic stem cells.

机译：CDK和细胞周期环节G（1）胚胎，神经和造血干细胞的长度和分化。

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摘要

It is long known that stem cell differentiation correlates with a lengthening of the cell cycle, in particular G(1). Moreover, models were proposed for mammalian embryonic, neural and hematopoietic stem cells whereby lengthening of G(1) is a cause, rather than a consequence, of differentiation. These models are based on the concept that time, i.e.,: G(1) length, may be a limiting factor for cell fate change to occur because differentiation factors require time in order to trigger a physiological response. Despite the many correlative studies, this hypothesis proved difficult to demonstrate because most trophic, signaling or transcription factors involved in stem cell differentiation may concurrently, but independently, also have an effect on cell cycle progression, which calls for a thorough review on the differentiation role of genes whose best characterized and long established function is exclusively to control G(1). For this reason, we here focus our attention on the effects that the core molecular machinery controlling G(1) progression, i.e.,: the G(1)-specific cyclin dependent kinase (cdk)/cyclin complexes, have on stem cell differentiation. In particular, we will discuss the effects of G(1)-cdks/cyclins on differentiation of embryonic, neural and hematopoietic stem cells during development and adulthood, for which a role of G(1) length has been proposed.
机译：众所周知，干细胞分化与细胞周期的延长相关，特别是G（1）相关。此外，提出了哺乳动物胚胎，神经和造血干细胞的模型，从而延长G（1）是分化的原因，而不是结果。这些模型基于该概念，即时间，即：g（1）长度，可以是小区命运变化的限制因素，因为分化因子需要时间以触发生理响应。尽管有许多相关性研究，但该假设证明难以证明，因为涉及干细胞分化的大多数营养，信号或转录因子可能同时但独立地对细胞周期进展产生了影响，这需要彻底审查分化作用最佳特征和长期功能的基因仅限于控制G（1）。出于这个原因，我们在这里集中注意力控制G（1）进展的核心分子机械，即，：：G（1） - 特异性细胞周期蛋白依赖性激酶（CDK）/细胞周期蛋白复合物对干细胞分化具有。特别是，我们将讨论G（1）-cdks / cyclins在发育过程中和成年期间对胚胎，神经和造血干细胞的分化的影响，其中提出了G（1）长度的作用。

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  • 来源
    《Cell cycle》 |2010年第10期|共8页
  • 作者

    Calegari F;

  • 作者单位

    DFG-Research Center and Cluster of Excellence for Regenerative Therapies Dresden (CRTD) Medical Faculty Technische Universitat Dresden Germany.;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
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