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首页> 外文期刊>Cell stem cell >Dedifferentiated Schwann Cell Precursors Secreting Paracrine Factors Are Required for Regeneration of the Mammalian Digit Tip
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Dedifferentiated Schwann Cell Precursors Secreting Paracrine Factors Are Required for Regeneration of the Mammalian Digit Tip

机译：哺乳动物数字尖端的再生需要分泌旁静脉因子的去细胞化施旺细胞前体

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SUMMARY Adult mammals have lost multi-tissue regenerative capacity, except for the distal digit, which is able to regenerate via mechanisms that remain largely unknown. Here, we show that, after adult mouse distal digit removal, nerve-associated Schwann cell precursors (SCPs) dedifferentiate and secrete growth factors that promote expansion of the blastema and digit regeneration. When SCPs were dys-regulated or ablated, mesenchymal precursor proliferation in the blastema was decreased and nail and bone regeneration were impaired. Transplantation of exogenous SCPs rescued these regeneration defects. We found that SCPs secrete factors that promote self-renewal of mesenchymal precursors, and we used transcriptomic and proteomic analysis to define candidate factors. Two of these, oncosta-tin M (OSM) and platelet-derived growth factor AA (PDGF-AA), are made by SCPs in the regenerating digit and rescued the deficits in regeneration caused by loss of SCPs. As all peripheral tissues contain nerves, these results could have broad implications for mammalian tissue repair and regeneration.
机译：摘要成年哺乳动物失去了多组织再生能力，除了远端数字，能够通过仍然很大程度上未知的机制再生。在这里，我们表明，在成人小鼠远端的去除后，神经相关的氏武农细胞前体（SCPS）消化不良和分泌生长因子，促进Blastema和数字再生的扩张。当SCPS受到缓解或烧蚀时，Blastema中的间充质前体增殖降低，并且削弱钉子和骨再生。外源SCP的移植救出了这些再生缺陷。我们发现SCPS分泌因子促进间充质前体的自我更新，并且我们使用转录组和蛋白质组学分析来定义候选因子。其中两种，oncosta-tiN m（OSM）和血小板衍生的生长因子AA（PDGF-AA）由再生数字中的SCP制造，并拯救由SCP损失引起的再生中的缺陷。随着所有外周组织含有神经，这些结果可能对哺乳动物组织修复和再生具有广泛的影响。

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