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首页> 外文期刊>Cellular Signalling >MALAT1 overexpression promotes the growth of colon cancer by repressing beta-catenin degradation
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MALAT1 overexpression promotes the growth of colon cancer by repressing beta-catenin degradation

机译：Malat1过度表达通过抑制β-catenin降解来促进结肠癌的生长

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摘要

Colon cancer is one of the most common types of cancer and more than 80% of colon cancer cases are associated with Wnt-beta-catenin signaling activation. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a multi-functional long non-coding RNA that is overexpressed in many types of cancers, including colon cancer. In this study, MALAT1 and beta-catenin were found to be overexpressed in tumor samples from 62 patients with colon cancer. A positive correlation was identified between MALAT1 levels and beta-catenin protein levels in tumors. MALAT1 was found to upregulate beta-catenin protein levels in HCT116 and LOVO cells without changing the mRNA expression levels. beta-catenin degradation was confirmed to be upregulated in MALAT1-knockdown cells and inhibited in cells overexpressing MALAT1 overexpressing. MALAT1 was then identified as a negative regulator of GSK-3 beta; it did so via promotion of H3K27 trimethylation of the promoter region. In conclusion, MALAT1 is an oncogene in colon cancer, which inhibits beta-catenin degradation by upregulating H3K27 trimethylation and repressing GSK-3 beta expression.
机译：结肠癌是最常见的癌症类型之一，超过80％的结肠癌病例与Wnt-β-连环素信号传导激活有关。转移相关的肺腺癌转录物1（Malat1）是一种多功能长的非编码RNA，其在许多类型的癌症中过表达，包括结肠癌。在本研究中，发现Malat1和β-连环蛋白在来自62名结肠癌患者的肿瘤样品中过表达。在肿瘤中的Malat1水平和β-连环蛋白蛋白水平之间鉴定了阳性相关性。发现马拉特1在HCT116和Lovo细胞中上调β-连环蛋白蛋白水平而不改变mRNA表达水平。确认β-连续素降解在Malat1敲低细胞中上调，并抑制过表达Malat1过表达的细胞。然后将Malat1鉴定为GSK-3β的负调节剂;它通过促进启动子区域的H3K27三甲基化而这样做。总之，马拉特1是结肠癌的癌基因，通过上调H3K27三甲基化并抑制GSK-3β表达来抑制β-连环蛋白降解。

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  • 来源
    《Cellular Signalling》 |2020年第1期|共8页
  • 作者

    Zheng Xiaoying; Ren Jianhua; Peng Bingjun; Ye Junling; Wu Xinchun; Zhao Wenhui; Li Yanjun; Chen Ruihui; Gong Xue; Bai Chengmei; Wang Yating; Zhao Haiyun; Zhang Yiqing;

  • 作者单位

    Qinghai Univ Dept Pathol Affiliated Hosp Xining 810001 Qinghai Peoples R China;

    Chengde Cent Hosp Dept EEG &

    Neuromyoelect Diag Chengde 067000 Hebei Peoples R China;

    Qinghai Univ Dept Med Imaging Ctr Affiliated Hosp Xining 810001 Qinghai Peoples R China;

    Qinghai Univ Dept Pathol Affiliated Hosp Xining 810001 Qinghai Peoples R China;

    Qianxi Cty Peoples Hosp Dept 4 Tangshan 064308 Hebei Peoples R China;

    Qinghai Univ Dept Pathol Affiliated Hosp Xining 810001 Qinghai Peoples R China;

    Qinghai Univ Dept Pathol Affiliated Hosp Xining 810001 Qinghai Peoples R China;

    Qinghai Univ Dept Pathol Affiliated Hosp Xining 810001 Qinghai Peoples R China;

    Qinghai Univ Dept Pathol Affiliated Hosp Xining 810001 Qinghai Peoples R China;

    Qinghai Univ Dept Pathol Affiliated Hosp Xining 810001 Qinghai Peoples R China;

    Qinghai Univ Dept Pathol Affiliated Hosp Xining 810001 Qinghai Peoples R China;

    Menyuan Hui Autonomous Cty Tradit Chinese Med Hos Xining 810300 Qinghai Peoples R China;

    Qinghai Univ Dept Pathol Affiliated Hosp Xining 810001 Qinghai Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞形态学;
  • 关键词

    Colon cancer; MALAT1; beta-Catenin; H3K27me3; GSK-3 beta;

    机译：结肠癌;Malat1;β-catenin;H3K27ME3;GSK-3 Beta;

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