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Involvement of hyaluronan and CD44 in cancer and viral infections

机译:透明质酸和CD44在癌症和病毒感染中的参与

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Hyaluronan and its major receptor CD44 are ubiquitously distributed. They have important structural as well as signaling roles, regulating tissue homeostasis, and their expression levels are tightly regulated. In addition to signaling initiated by the interaction of the intracellular domain of CD44 with cytoplasmic signaling molecules, CD44 has important roles as a co-receptor for different types of receptors of growth factors and cytokines. Dysregulation of hyaluronan-CD44 interactions is seen in diseases, such as inflammation and cancer. In the present communication, we discuss the mechanism of hyaluronan-induced signaling via CD44, as well as the involvement of hyaluronan-engaged CD44 in malignancies and in viral infections.
机译:透明质酸及其主要受体CD44普遍存在。 它们具有重要的结构和信号角色,调节组织稳态,并且它们的表达水平严格调节。 除了通过CD44与细胞质信号分子的细胞内结构域的相互作用引发的信号传导,CD44还具有作为生长因子和细胞因子的不同类型受体的共同受体的重要作用。 在疾病和癌症等疾病中观察到透明质酸-CD44相互作用的失调。 在目前的通信中,我们讨论了通过CD44探讨了透明质酸诱导的信号传导的机制,以及透明化植物接合的CD44在恶性肿瘤中和病毒感染中的参与。

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