MiR-675 is frequently overexpressed in gastric cancer and enhances cell proliferation and invasion via targeting a potent anti-tumor gene PITX1

Liu Lei; Tian Yan-Chun; Mao Gang; Zhang Yun-Gui; Han Li

首页> 外文期刊>Cellular Signalling >MiR-675 is frequently overexpressed in gastric cancer and enhances cell proliferation and invasion via targeting a potent anti-tumor gene PITX1

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MiR-675 is frequently overexpressed in gastric cancer and enhances cell proliferation and invasion via targeting a potent anti-tumor gene PITX1

机译：miR-675经常在胃癌中过表达，并通过靶向效率的抗肿瘤基因pitx1来增强细胞增殖和侵袭

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Background: Gastric cancer (GC) is a common malignancy around the world. Irregular expression of microRNAs (miRNAs) contributes to the progression of malignancies. Our study illustrated that miR-675 facilitates GC proliferation and invasion via targeting paired-like homeodomain transcription factor 1 (PITX1) and promoting epithelial-mesenchymal transition (EMT) as well as Wnt/beta-catenin signaling pathway.

机译：背景：胃癌（GC）是世界各地的常见恶性肿瘤。 MicroRNA的不规则表达（miRNA）有助于恶性肿瘤的进展。我们的研究表明，MIR-675通过靶向类似的同源域转录因子1（PITX1）促进GC增殖和侵袭，并促进上皮 - 间充质转换（EMT）以及WNT /β-连环蛋白信号传导途径。

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来源
《Cellular Signalling》 |2019年第2019期|共11页
作者
Liu Lei; Tian Yan-Chun; Mao Gang; Zhang Yun-Gui; Han Li;
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作者单位

Fourth Peoples Hosp Jinan Dept Gastroenterol Jinan Shandong Peoples R China;

Fourth Peoples Hosp Jinan Sterrilizat &

Suplly Ctr Jinan Shandong Peoples R China;

Fourth Peoples Hosp Jinan Emergency Dept Jinan Shandong Peoples R China;

Fourth Peoples Hosp Jinan Dept Gastroenterol Jinan Shandong Peoples R China;

Fourth Peoples Hosp Jinan Qual Control Management Off 50 Shifan Rd Jinan Shandong Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类细胞形态学;
关键词
miR-675; PITX1; Gastric cancer; Invasion; EMT;

机译：mir-675;pitx1;胃癌;入侵;emt;

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专利

1. MiR-675 is frequently overexpressed in gastric cancer and enhances cell proliferation and invasion via targeting a potent anti-tumor gene PITX1 [J] . Liu Lei, Tian Yan-Chun, Mao Gang, Cellular Signalling . 2019,第期

机译：miR-675经常在胃癌中过表达，并通过靶向效率的抗肿瘤基因pitx1来增强细胞增殖和侵袭
2. Overexpressed miR-301a promotes cell proliferation and invasion by targeting RUNX3 in gastric cancer [J] . WangM., LiC., YuB., Journal of gastroenterology . 2013,第9期

机译：胃癌中过表达的miR-301a通过靶向RUNX3促进细胞增殖和侵袭
3. MiR-208a enhances cell proliferation and invasion of gastric cancer by targeting SFRP1 and negatively regulating MEG3 [J] . Hai-Bin Cui, Huai-E Ge, Yong-Sen Wang, The international journal of biochemistry and cell biology . 2018,第期

机译：MiR-208A通过靶向SFRP1和负调节MEG3来增强细胞增殖和胃癌的侵袭
4. hERGl Channels Are Overexpressed in Human Gastric Cancer and Their Activity Regulates Cell Proliferation: A Novel Prognostic and Therapeutic Target? [C] . E Lastraioli, F. Gasperi Campani, A. Taddei, International Gastric Cancer Congress . 2005

机译：Hergl频道在人胃癌中过表达，其活性调节细胞增殖：一种新的预后和治疗靶标？
5. Design and Evaluation of Peptidomimetics and Peptidomimetics Drug Conjugates Targeting HER2 Overexpressing Cells in Breast and Lung Cancers [D] . Pallerla, Sandeep. 2017

机译：拟肽和拟肽药物结合物靶向乳腺癌和肺癌中HER2过表达细胞的设计和评估
6. Long Noncoding RNA H19-Derived miR-675 Enhances Proliferation and Invasion via RUNX1 in Gastric Cancer Cells [O] . Gao Liu, Tian Xiang, Quan-Feng Wu, 2016

机译：长度非致RNA H19-衍生的miR-675通过Runx1在胃癌细胞中增强增殖和侵袭
7. miR-4262, low level of which predicts poor prognosis, targets proto-oncogene CD163 to suppress cell proliferation and invasion in gastric cancer [O] . Hongzhi Zhang, Huijuan Jiang, Huixiang Zhang, 2019

机译：miR-4262，低水平预测预后差，靶向癌基因CD163抑制胃癌中的细胞增殖和侵袭

MiR-675 is frequently overexpressed in gastric cancer and enhances cell proliferation and invasion via targeting a potent anti-tumor gene PITX1

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