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首页> 外文期刊>Cellular Signalling >Role of Akt signaling pathway regulation in the speckled mousebird (Colius striatus) during torpor displays tissue specific responses
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Role of Akt signaling pathway regulation in the speckled mousebird (Colius striatus) during torpor displays tissue specific responses

机译：AKT信号通路调节在Torpor期间在斑点鼠标鸟类（Colius Striatus）中的作用显示了组织特定响应

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摘要

Pronounced heterothermic responses are relatively rare among birds. Along with taxa such as hummingbirds and caprimulgids, the order Coliiformes (mousebirds) is known to possess the physiological capacity for torpor. During torpor, body temperature is greatly reduced and a bird becomes unresponsive to external stimuli until ambient temperatures return to more favorable conditions. Under such conditions, these birds are forced to rely only on their internal fuel storage for energy and show great reduction in metabolic rates by decreasing energy -expensive processes. This study investigated the role of the key insulin-Akt signaling kinase pathway involved in regulating energy metabolism and protein translation in the liver, kidney, heart, skeletal muscle, and brain of the speckled mousebird (Colius striatus). The degree of phosphorylation of well-conserved target residues with important regulatory function was examined in both the euthermic control and torpid birds. The results demonstrated marked differences in responses between the tissues with decreases in RPS6 S235/236 phosphorylation in the kidney (0.52 fold of euthermic) and muscle (0.29 fold of euthermic) as well as decreases in GS3K3 beta S9 in muscle (0.60 fold of euthermic) and GSK3 alpha S21 (0.71 fold of euthermic) phosphorylation in kidney during torpor, suggesting a downregulation of this pathway. Interestingly, the liver demonstrated an increase in RPS6 S235/236 (2.89 fold increase) and P70S6K T412 (1.44 fold increase) phosphorylation in the torpor group suggesting that protein translation is maintained in this tissue. This study demonstrates that avian torpor is a complex phenomenon and alterations in this signaling pathway follow a tissue specific pattern.
机译：明显的异质反应在鸟类中相对罕见。除了蜂鸟和潮帽等分类群，已知订单Coliiformes（Mousebirds）拥有托麦特的生理能力。在扭力期间，体温大大减少，鸟对外部刺激无响应，直到环境温度恢复更有利的条件。在这种情况下，这些鸟类被迫仅依赖于其内部燃料储存的能量，并通过降低能量稠度的过程来显示代谢率的大大降低。本研究调查了关键胰岛素-AKT信号传导激酶途径参与调节能量代谢和蛋白质翻译的关键胰岛素-AKT信号通孔途径在肝脏，肾脏，心脏，骨骼肌和斑点鸟鸟（Colius Striatus）的脑中进行脑斑块的作用。在效果对照和扭矩鸟类中检查了具有重要调节功能的保守靶分之残留物的磷酸化程度。结果表明，肾脏（Euthermic的0.52倍）和肌肉（Euthermic的0.52倍）和肌肉（0.29倍）的肌肉（0.29倍）中的磷酸化和肌肉中的肌肉（0.60倍的euthermic（Euthermic）的降低，结果表现出显着的差异在Torpor期间，肾脏中肾脏的GSK3αS21（Euthermic）磷酸化的GSK3αS21（0.71倍），表明该途径的下调。有趣的是，肝脏显示RPS6 S235 / 236（2.89倍）的增加（2.89倍增加），TORPOR组中的P70S6K T412（1.44倍增加）磷酸化，表明该组织中保持蛋白质翻译。本研究表明，禽晕孢子是该信号传导途径中的复杂现象和改变，遵循组织特异性图案。

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