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首页> 外文期刊>Cell transplantation >Bexarotene Exerts Protective Effects Through Modulation of the Cerebral Vascular Smooth Muscle Cell Phenotypic Transformation by Regulating PPAR gamma/FLAP/LTB4 After Subarachnoid Hemorrhage in Rats
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Bexarotene Exerts Protective Effects Through Modulation of the Cerebral Vascular Smooth Muscle Cell Phenotypic Transformation by Regulating PPAR gamma/FLAP/LTB4 After Subarachnoid Hemorrhage in Rats

机译：通过调节大鼠蛛网膜下腔出血后通过调节PPARγ/ PLAP / LTB4来调节脑血管平滑肌细胞表型转化的脑血管平滑肌细胞表型转化施加保护作用

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摘要

Vascular smooth muscle cells (VSMCs) play an important role after a subarachnoid hemorrhage (SAH). The changes in VSMCs following bexarotene treatment after SAH are unknown. In the present study, neurological impairment, decreased cerebral cortical blood flow and transformation of cerebral VSMCs from a contractile to a synthetic phenotype were observed after SAH. Bexarotene reduced neurological impairment, improved cerebral cortical blood flow, inhibited VSMC phenotypic transformation and suppressed the expression of 5-lipoxygenase-activating protein (FLAP) and leukotriene B4 (LTB4), which was partly reversed by GW9662, an inhibitor of peroxisome proliferator-activated receptor gamma (PPAR gamma). Mechanistically, sh-PPAR gamma-mediated phenotypic transformation of VSMCs was partially suppressed by MK886, an antagonist of FLAP. Therefore, we conclude that bexarotene reduced neurological impairment, improved cerebral cortical blood flow and inhibited the VSMC phenotypic transformation after SAH, which was achieved by activating PPAR gamma-mediated inhibition of FLAP/LTB4 in VSMCs
机译：血管平滑肌细胞（VSMCs）在蛛网膜下腔出血（SAH）后发挥着重要作用。在SAH后贝卡罗琳治疗后VSMCs的变化是未知的。在本研究中，在SAH后观察到脑皮质损伤，降低脑皮质血流和来自收缩到合成表型的脑VSMC的转化。 Bexarotene降低神经损伤，改善脑皮质血流，抑制VSMC表型转化并抑制了5-脂氧基酶活化蛋白（襟翼）和白酮B4（LTB4）的表达，其部分反向了过氧化物酶促增殖物激活的过氧化物体增殖物抑制剂受体γ（PPAR Gamma）。机械地，通过MK886，瓣膜拮抗剂部分抑制了VSMCs的SH-PPARγ介导的比例转化。因此，我们得出结论，贝卡罗琳降低了神经损伤，改善了脑皮质血液流动并抑制了SAH后的VSMC表型转化，这是通过激活PPARγ介导的瓣/ LTB4在VSMC中的瓣膜/ LTB4抑制来实现的

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  • 来源
    《Cell transplantation》 |2019年第10期|共12页
  • 作者

    Zhang Zhaosi; Zhao Guosheng; Liu Liu; He Junchi; Darwazeh Rami; Liu Han; Chen Hong; Zhou Chao; Guo Zongduo; Sun Xiaochuan;

  • 作者单位

    Chongqing Med Univ Affiliated Hosp 1 Dept Neurosurg Chongqing 400016 Peoples R China;

    Chongqing Med Univ Affiliated Hosp 1 Dept Orthoped Surg Chongqing Peoples R China;

    Chongqing Med Univ Affiliated Hosp 1 Dept Neurosurg Chongqing 400016 Peoples R China;

    Chongqing Med Univ Affiliated Hosp 1 Dept Neurosurg Chongqing 400016 Peoples R China;

    Chongqing Med Univ Affiliated Hosp 1 Dept Neurosurg Chongqing 400016 Peoples R China;

    Chongqing Med Univ Affiliated Hosp 1 Dept Neurosurg Chongqing 400016 Peoples R China;

    Chongqing Med Univ Affiliated Hosp 1 Dept Neurosurg Chongqing 400016 Peoples R China;

    Chongqing Med Univ Affiliated Hosp 1 Dept Neurosurg Chongqing 400016 Peoples R China;

    Chongqing Med Univ Affiliated Hosp 1 Dept Neurosurg Chongqing 400016 Peoples R China;

    Chongqing Med Univ Affiliated Hosp 1 Dept Neurosurg Chongqing 400016 Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 治疗学;
  • 关键词

    Bexarotene; subarachnoid hemorrhage; vascular smooth muscle cells; PPAR gamma; FLAP;

    机译：Bexarotene;蛛网膜下腔出血;血管平滑肌细胞;PPAR伽玛;皮瓣;

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