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首页> 外文期刊>Cardiovascular revascularization medicine: including molecular interventions >Reproducibility of Semi-automated Three-dimensional Volumetric Analysis using Cardiac Computed Tomography in Patients With Left Ventricular Assist Device
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Reproducibility of Semi-automated Three-dimensional Volumetric Analysis using Cardiac Computed Tomography in Patients With Left Ventricular Assist Device

机译：左心室辅助装置患者心脏计算断层扫描的半自动三维体积分析的再现性

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Background: Multi-detector gated cardiac computed tomography (CCT) allows three-dimensional (3D) quantification of cardiac chambers and is clinically indicated to assess left ventricular assist device (LVAD) malfunction and complications. Automated volumetric analysis is, however, disrupted by inflow cannula artifact in patients with LVAD. With this study, we evaluated intra-observer variability in semi-automated 3D cardiac volumetric analysis using CCT in patients with LVADs. Methods: Ten clinically indicated CCTs were studied retrospectively from 9 patients with LVADs. 3D chamber quantification included left and right ventricles end-systolic and end-diastolic volumes (ESV, EDV); and left and right atrial ESV. Derived measurements included cardiac output (CO), ejection fraction (EF), and stroke volume (SV). Automated volumetric analysis was performed, and manual corrections were added when necessary. Absolute and relative differences, Bland-Altman plots, and interclass correlation coefficients (ICCs) were used to assess intra-observer reproducibility for these measurements. Results: Intra-observer reproducibility was excellent for volumetric (ICC >0.99) and derived data (ICC >0.91). Comparing right vs left heart volumetric assessments, the former had a higher relative difference (atria 2.8% vs 1.6%, ESV 3.0% vs 1.9%, EDV 2.7% vs 1.3%), which also translated to a greater relative difference in right-side derived data (CO 11.1% vs. 8.8%, EF 10.5% vs. 9.9%, SV 10.9% vs. 9.0%). The mean difference in left ventricular ejection fraction was 0.4% (limits of agreement [LOA]: —2 and 3.2) and right ventricular ejection fraction was 1.2% (LOA: -4.7 and 7.1). Conclusions: Our results for semi-automated 3D volumetric analysis showed excellent reproducibility for both volumetric and derived data. Summary: Electrocardiography-gated cardiac computed tomography with semi-automated volumetric analysis has excellent reproducibility in patients with left ventricular assist device making it imaging modality of choice for functional assessment in this patient population, where cardiac magnetic resonance imaging is contraindi-cated and transthoracic echocardiography may be limited by poor acoustic windows.
机译：背景：多检测器门控心脏计算机断层扫描（CCT）允许心室的三维（3D）量化，并在临床上表明评估左心室辅助装置（LVAD）发生故障和并发症。然而，自动体积分析由LVAD患者中的流入套管术士中断。通过这项研究，我们在LVAD患者中使用CCT评估了在半自动3D心脏体积分析中的观察者内变异性。方法：从9例LVAD患者回顾性如何研究十个临床上的CCT。 3D室定量包括左和右心室结束 - 末端和末端舒张型（ESV，EDV）;左和右心房ESV。衍生的测量包括心输出（CO），喷射分数（EF）和行程体积（SV）。进行自动体积分析，必要时添加手动校正。绝对和相对差异，Bland-Altman图和杂交相关系数（ICC）用于评估观察到的这些测量的帧内再现性。结果：体积（ICC> 0.99）和衍生数据（ICC> 0.91）的观察室内的再现性优异。比较右对比左心体积评估，前者相对差异更高（Atria 2.8％与1.6％，ESV 3.0％Vs 1.9％，EDV 2.7％Vs 1.3％），也转化为右侧的相对相对差异衍生数据（CO 11.1％与8.8％，EF 10.5％与9.9％，SV 10.9％与9.0％）。左心室喷射分数的平均差异为0.4％（协议的限值[LOA]：-2和3.2），右心室喷射分数为1.2％（LOA：-4.7和7.1）。结论：我们对半自动3D体积分析的结果显示出对体积和衍生数据的优异再现性。概述：具有半自动体积分析的心电图 - 门控制断层扫描具有优异的左心室辅助设备患者的再现性，使其在该患者群体中的功能评估中的功能性评估的成像形式，其中心脏磁共振成像是禁忌的和ransthoracic超声心动图可能受到糟糕的声学窗口的限制。

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