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首页> 外文期刊>Acta ophthalmologica Scandinavica >Ocular blood flow and oxygen delivery to the retina in primary open-angle glaucoma patients: the addition of dorzolamide to timolol monotherapy
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Ocular blood flow and oxygen delivery to the retina in primary open-angle glaucoma patients: the addition of dorzolamide to timolol monotherapy

机译：原发性开角型青光眼患者的眼血流量和向视网膜的氧气输送：在替莫洛尔单药治疗中加用多佐胺

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Purpose: To assess the effects of adding dorzolamide to timolol monotherapy on ocular haemodynamics and retinal oxygen saturation in patients with primary open-angle glaucoma (POAG).Methods: Twenty-four patients (12 healthy, 12 with POAG) were treated with dorzo-lamide/timolol combination (DT) versus timolol maleate 0.5% twice daily in a randomized, crossover, double-blind study conducted over a period of 18 months. Patients received each treatment for 8 months then crossed over to the other treatment after a 1-month washout and second baseline. Goldmann applanation tonometry, Heidelberg retinal flowmetry (HRF), colour Doppler imaging (CDI) and retinal photographic oximetry were performed at each visit.Results: DT significantly reduced intraocular pressure (IOP) in both glaucomatous [right eye (OD) -13.15%, left eye (OS) -14.43%; p < 0.036] and non-glaucomatous (OD -12.4%, OS -13.88%; p < 0.039) patients compared to timolol after 8 months of treatment. DT significantly reduced the number of zero blood flow pixels in the superior (-39.72%; p < 0.014) and inferior (-51.44%; p < 0.008) retina in the non-glaucomatous group and inferior retina in the glaucomatous group (-55.38%, p < 0.006). The continuation of timolol monotherapy from baseline did not change (p < 0.05) any measured parameter and neither treatment had a significant effect (p < 0.05) on retinal oximetry or CDI parameters.Conclusion: The addition of dorzolamide to timolol monotherapy decreases IOP and increases retinal blood flow in the superficial retinal vasculature in both glaucomatous and healthy patients following 8 months of treatment. The combination of increased retinal blood flow with consistent oxygen saturation may potentially increase oxygen delivery to the retina.
机译：目的：评估替莫洛尔单药治疗中加用多佐胺对原发性开角型青光眼（POAG）患者眼血流动力学和视网膜血氧饱和度的影响。方法：对二十四例患者（12例健康，其中12例采用POAG）进行了多佐唑治疗。在为期18个月的随机，交叉，双盲研究中，每天两次用lamide / timolol组合（DT）与马来酸替莫洛尔混合0.5％。患者接受每种治疗8个月，然后经过1个月的冲洗和第二次基线后转到另一种治疗。每次访视均进行了戈德曼压平眼压计，海德堡视网膜血流计（HRF），彩色多普勒成像（CDI）和视网膜照相血氧测定法。结果：DT显着降低了青光眼[右眼（OD）-13.15％，左眼（OS）-14.43％; p <0.036]和非青光眼（OD -12.4％，OS -13.88％; p <0.039）的患者与替莫洛尔治疗8个月后相比。 DT显着减少了非青光眼组视网膜上（-39.72％; p <0.014）和下视网膜（-51.44％; p <0.008）的零血流像素数量，以及青光眼组（-55.38）的视网膜下视网膜％，p ＜0.006）。噻吗洛尔单药治疗从基线开始的持续性没有改变（p <0.05）任何测量参数，并且两种治疗均未对视网膜血氧饱和度或CDI参数产生显着影响（p <0.05）。结论：替莫洛尔单药治疗中添加多佐胺会降低IOP并增加治疗8个月后，青光眼和健康患者的浅表视网膜脉管系统中的视网膜血流。视网膜血流增加与持续的氧饱和度相结合，可能会增加氧向视网膜的输送。

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