Synthesis and inhibitory activity of 1,3-(adamantan-1(2)-yl)- imidazolidine-2,4,5-triones and 3,3'-(adamantan-1-yl)- bis(1-alkylimidazolidine-2,4,5-triones)

Dyachenko Vladimir S.; Burmistrov Vladimir V.; Nishi Kosuke; Kim In-Hae; Butov Gennady M.

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Synthesis and inhibitory activity of 1,3-(adamantan-1(2)-yl)- imidazolidine-2,4,5-triones and 3,3'-(adamantan-1-yl)- bis(1-alkylimidazolidine-2,4,5-triones)

机译：1,3-（亚丹坦-1（2） - 基 - 咪唑烷-2,4,5-三＆3,3' - （1-烷基咪唑烷-2,4,5-三酮）的合成和抑制活性

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A series of 1,3-(adamantan-1(2)-yl)imidazolidine-2,4,5-triones and 1,1'-(alkane-1,n-diyl)bis[3-(adamantan-1-yl)imidazolidine-2,4,5-triones] was synthesized via cyclization of 1,3-bis[adamantan-1(2)-ylureas] and 1,1'-(alkyl-1,n-diyl)bis[3-(adamantan-1-yl)ureas] with oxalyl chloride under mild conditions with high yields. All synthesized compounds were tested in vitro as inhibitors of soluble human epoxide hydrolase. A number of compounds have high inhibitory activity (IC50 1.6-650 nM), which makes them promising inhibitors of soluble epoxide hydrolase.

机译：一系列1,3-（Adamantan-1（2） - 基 - 基咪唑烷-2,4,5- Triones和1,1' - （烷烃-1，N-二基）BIS [3-（Adamantan-1- 通过1,3-双烷基-1（2） - 脲脲]和1,1' - （烷基-1，N-二基）BIS [3 - （Adamantan-1-Y1）尿布，在温和条件下具有高产率的草酰氯。作为可溶性人环氧化物水解酶的抑制剂，在体外测试所有合成的化合物。许多化合物具有高抑制活性（IC50 1.6-650nm），这使得它们具有可溶性环氧化物水解酶的有前途抑制剂。

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来源
《Chemistry of heterocyclic compounds》 |2017年第10期|共4页
作者
Dyachenko Vladimir S.; Burmistrov Vladimir V.; Nishi Kosuke; Kim In-Hae; Butov Gennady M.;
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作者单位

Volgograd State Tech Univ Volzhsky Polytech Inst Branch 42a Engelsa St Volzhsky 404121 Russia;

Volgograd State Tech Univ Volzhsky Polytech Inst Branch 42a Engelsa St Volzhsky 404121 Russia;

Ehime Univ Dept Biol Fac Sci 3-5-7 Tarumi Matsuyama Ehime 7908566 Japan;

Ehime Univ Dept Biol Fac Sci 3-5-7 Tarumi Matsuyama Ehime 7908566 Japan;

Volgograd State Tech Univ Volzhsky Polytech Inst Branch 42a Engelsa St Volzhsky 404121 Russia;

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原文格式 PDF
正文语种 eng
中图分类杂环化合物;
关键词
adamantane; imidazolidine-2; 4; 5-trione; oxalylurea; parabanic acid; soluble epoxide hydrolase; inhibitor;

机译：金刚烷;咪唑烷-2;4;5-Trione;oxalylurea;羟甲酸;可溶的环氧化物水解酶;抑制剂;

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1. Synthesis and inhibitory activity of 1,3-(adamantan-1(2)-yl)- imidazolidine-2,4,5-triones and 3,3'-(adamantan-1-yl)- bis(1-alkylimidazolidine-2,4,5-triones) [J] . Dyachenko Vladimir S., Burmistrov Vladimir V., Nishi Kosuke, Chemistry of heterocyclic compounds . 2017,第10期

机译：1,3-（亚丹坦-1（2） - 基 - 咪唑烷-2,4,5-三＆3,3' - （1-烷基咪唑烷-2,4,5-三酮）的合成和抑制活性
2. Synthesis and antimicrobial activity of sulphamethoxazole-based ureas and imidazolidine-2,4,5-triones [J] . Kratky Martin, Mandikova Jana, Trejtnar Frantisek, Chemicke Zvesti . 2015,第8期

机译：磺胺甲基恶唑基脲和咪唑烷-2,4,5-三酮的合成及抑菌活性
3. Simple Synthesis of Imidazolidinetrione Derivatives Having Imidazolidine-2,4,5-trione and 2-Thioxo-imidazolidine-4,5-dione Rings [J] . Y.-G. Lee, D.-I. Jung, Y-H. Kim Polish Journal of Chemistry . 2009,第10期

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机译：Bimetallomesogens：3,3' - （2-羟基丙烷-1,3-DIY ）双（二氧化氮-1-基-1- ylidene）双（2-（4-烷氧基苯基）PR-1的铜互联的合成和侧聚态性质-en-1-ol）
5. 1. ortho-linked polyaryloxide and sterically hindered biphenoxide ligands: Synthesis and metal coordination chemistry. 2. Synthesis, characterization, and reactivity of bis[hydrotris(pyrazol-1-yl)borato]titanium(II). [D] . Kayal, Ajay. 2002

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6. 4-Methyl-1,3-bis(3,4-methylenedioxybenzyl)-2-(3,4-methylenedioxyphenyl)imidazolidine [O] . Shu-Ping Yang, Li-Jun Han, Ai-Ping Wen, 2016

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7. 1,3-Substituted Imidazolidine-2,4,5-triones: Synthesis and Inhibition of Cholinergic Enzymes [O] . Josef Jampilek, Ales Imramovsky, Zdenka Padelkova, 2011

机译：1,3-取代的咪唑烷-2,4,5-三酮类化合物：胆碱能酶的合成与抑制

Synthesis and inhibitory activity of 1,3-(adamantan-1(2)-yl)- imidazolidine-2,4,5-triones and 3,3'-(adamantan-1-yl)- bis(1-alkylimidazolidine-2,4,5-triones)

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