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Yttrium-90 - current status, expected availability and applications of a high beta energy emitter

机译：Yttrium-90-高β能量发射器的当前状态，预期可用性和应用

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摘要

Yttrium-90 ( 90Y, T1/2 64.14 h) is a key example of a high beta energy-emitting radionuclide which is available from the strontium-90 ( 90Sr)/ 90Y radionuclide generator system. Clinical uses of 90Y-labeled radiopharmaceutical agents have been pursued for many years and many applications have proven to be clinical effective. These most notably include the application of 90Y-labeled antibodies for a variety of applications such as for effective treatment of non-Hodgkin's lymphoma. One of the major advantages for use of 90Y is ready availability from the very long-lived 90Sr parent (T1/2 28.78 y). Because of the importance of maintaining generator performance and minimizing parent breakthrough, this paper describes development, use and quality control of both high capacity cation adsorption-type and electrochemical generator systems. In addition, the preparation and targeting to tumors in mice of DOTA-conjugated Nimotuzamab (h-R3) antibody which recognizes the external domain of the EPFR antibody radiolabeled with 90Y obtained from the electrochemical generator is also described. As a key example for clinical applications of 90Y, the use of 90Y-labeled biotin for intra-operative pre-targeting for radionuclide therapy (IART?) of breast cancer is also described.
机译：钇90（90Y，T1 / 2 64.14 h）是可从锶90（90Sr）/ 90Y放射性核素发生器系统获得的高β能量发射放射性核素的关键示例。多年来一直追求90Y标记的放射性药物的临床应用，并且许多应用已证明是临床有效的。这些最显着地包括将90Y标记的抗体用于多种应用，例如有效治疗非霍奇金淋巴瘤。使用90Y的主要优势之一是寿命很长的90Sr母体（T1 / 2为28.78 y）的可用性。由于保持发生器性能并最大程度地减少母体突破的重要性，本文介绍了高容量阳离子吸附式和电化学发生器系统的开发，使用和质量控制。另外，还描述了DOTA缀合的尼莫妥珠单抗（h-R3）抗体的制备和靶向小鼠中的肿瘤，该抗体识别由从电化学发生器获得的用90Y放射标记的EPFR抗体的外部结构域。作为90Y临床应用的关键实例，还描述了90Y标记的生物素在乳腺癌术中预靶向放射性核素治疗（IART？）中的用途。

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