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Glycemic Control Changes After Sleeve Gastrectomy

机译：套管胃切除术后血糖控制变化

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Purpose: Insulin resistance is prevalent in patients with obesity and type 2 diabetes (T2DM). The study aimed to assess the effects of laparoscopic sleeve gastrectomy (LSG) on body weight and glycemic status in patients with morbid obesity with and without T2DM.Methods: This prospective study involved 100 patients suffering from morbid obesity divided into two equal groups; 50 patients with T2DM and 50 nondiabetic patients, who were scheduled for LSG. The glycemic status was assessed before and after surgery by blood glucose levels, HbA1c, fasting insulin, c-peptide, and homeostasis model assessment of insulin resistance (HOMA-IR).Results: In the two groups, plasma glucose levels and HbA1c decreased significantly 1, 3, and 6 months after surgery relative to the preoperative readings. In the two groups, fasting insulin, C-peptide, and HOMA-IR decreased significantly 1, 3, and 6 months after surgery. There was no correlation between percentage of excess weight loss (%EWL) and C-peptide, HbA1c, fasting, and postprandial plasma glucose, fasting insulin, and HOMA-IR. C-peptide was correlated positively with HbA1c, fasting and postprandial plasma glucose, fasting insulin, and HOMA-IR.Conclusion: LSG produced a significant reduction in weight and body mass index in diabetic and nondiabetic patients 6 months after surgery with significant reduction of insulin resistance as early as 1 month after surgery independent of weight loss.
机译：目的：肥胖症患者和2型糖尿病（T2DM）患者中胰岛素抵抗普遍存在。该研究旨在评估腹腔镜套管胃切除术（LSG）对病态肥胖患者体重和血糖地位的影响，无论没有T2DM。方法：这项前瞻性研究涉及100名患有病态肥胖的患者分为两个相等的群体; 50例T2DM和50名非奶粉患者，被安排为LSG。在血糖水平，HBA1C，空腹胰岛素，C肽和胰岛素抵抗（HOMA-IR）的稳态模型评估之前和术前后评估血糖状态。结果：在两组中，血浆葡萄糖水平和HBA1c显着下降手术后1,3和6个月相对于术前读数。在两组中，手术后的禁食胰岛素，C肽和HOMA-IR显着下降1,3和6个月。过量减肥（％EWL）和C-肽，HBA1C，禁食和后血浆葡萄糖，空腹胰岛素和HOMA-IR之间没有相关性。 C-肽与HBA1C，禁食和餐后血浆葡萄糖，禁区胰岛素和HOMA-IR.CONCLUSECTION：LSG在手术后6个月内产生重量和体重指数的重量和体重指数显着降低，具有显着减少胰岛素的糖尿病抗性在手术后1个月，与减肥无关。

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