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首页> 外文期刊>Circulation journal >Smoking and smoking cessation in relation to all-cause mortality and cardiovascular events in 25,464 healthy male Japanese workers.
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Smoking and smoking cessation in relation to all-cause mortality and cardiovascular events in 25,464 healthy male Japanese workers.

机译：在25,464名健康男性日本工人中，吸烟和吸烟戒烟与全因死亡率和心血管事件相关。

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摘要

BACKGROUND: Smoking is still a major health problem among males in Japan. The effects of smoking and quitting on mortality and cardiovascular disease (CVD) need updating. METHODS AND RESULTS: This was a prospective cohort study with a median follow-up of 7.5 years of a total of 25,464 healthy male Japanese workers aged 20-61 years who were not on any medication. The adjusted hazard ratios (HR; 95% confidence interval) for all-cause death were 1.51 (0.73, 2.94), 1.68 (1.07, 2.70), 1.30 (0.70, 2.34), and those for total CVD events 1.91 (0.72, 4.67), 2.94 (1.65, 5.63), and 3.25 (1.69, 6.54) for light smokers (1-10 cigarettes/day), moderate smokers (11-20/day), and heavy smokers (>/= 21/day) compared to never-smokers, respectively. Total CVD events increased dose-dependently as the number of cigarettes/day increased. Acute myocardial infarction was increased at any level of smoking. Stroke was increased at a moderate level of smoking. Quitting for >/= 4 years, compared with continuing smokers, reduced the HR for all-cause death to 0.64 (0.38, 1.01), and total CVD events to 0.34 (0.17, 0.62). CONCLUSIONS: In healthy young- and middle-aged Japanese males, a significant increase in HR for total CVD events was confirmed for a smoking level of 11-20 cigarettes/day. Quitting reduced the HR for total CVD events, with quitting for >/= 4 years being statistically significant. A similar trend was observed for all-cause mortality.
机译：背景：吸烟仍然是日本男性中的主要健康问题。吸烟和戒烟对死亡率和心血管疾病（CVD）的影响需要更新。方法和结果：这是一项潜在的队列研究，中位随访7.5岁，共有25,464名健康男性日本工人，年龄在20-61岁的日本工人上没有任何药物。全因死亡的调整后的危险比（HR; 95％置信区间）为1.51（0.73,2.94），1.68（1.07,20.70），1.30（0.70,2.34），以及总CVD事件1.91（0.72,4.67 4.94（1.65,5.63）和3.25（1.69,6.54）为轻吸烟者（1-10支香烟/日），中度吸烟者（11-20 /天）和重型吸烟者（> / = 21 /日）到从不吸烟者。随着卷烟/日的数量增加，总CVD事件依赖性增加了剂量。在任何水平的吸烟水平都有急性心肌梗死。在适度的吸烟水平上增加了中风。与持续的吸烟者相比，戒烟> / = 4年来减少了所有导致死亡的人力资源，将HR降至0.64（0.38,1.01），总CVD事件为0.34（0.17,0.62）。结论：在健康的年轻和中年日本男性中，CVD事件总计的人力资源幅度大幅增加，达到了11-20支香烟/天的吸烟水平。退出总计CVD事件的人力资源，戒烟> / = 4年统计学意义。为全导致死亡率观察到类似的趋势。

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