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首页> 外文期刊>Clinical biomechanics >Experimental muscle pain of the vastus medialis reduces knee joint extensor torque and alters quadriceps muscle contributions as revealed through musculoskeletal modeling
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Experimental muscle pain of the vastus medialis reduces knee joint extensor torque and alters quadriceps muscle contributions as revealed through musculoskeletal modeling

机译：基础肌肉的实验肌肉疼痛可减少膝关节伸肌扭矩，并改变通过肌肉骨骼建模所揭示的Quadriceps肌肉贡献

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摘要

Background: Voluntary activation deficit of the quadriceps muscle group is a common symptom in populations with knee joint injury. Musculoskeletal modeling and simulations can improve our understanding of pathological conditions; however, they are mathematically complex which can limit their clinical application. A practical subject-specific modeling framework is introduced to evaluate knee extensor inhibition and muscle force contributions to isometric knee joint torques in healthy adults with and without experimentally induced quadriceps muscle pain. Methods: A randomized cross-over placebo controlled study design was used. Subject-specific maximum knee joint extension torque and quadriceps electromyographic data from 13 uninjured young adults were combined in a modeling framework to determine optimal muscle strength scaling parameters and ideal torque. Strength deficit ratios (experimental torque/ideal torque) and individual muscle contribution to experimental torque was computed before and after intramuscular hypertonic (pain inducing) and isotonic (sham) saline was injected to the vastus medialis. Findings: Decreased experimental knee extension torque (- 8%) and vastus medialis electromyography (- 26%) amplitude pre- to post- hypertonic injection was observed. Correspondingly, significant decreases in the knee extensor strength deficit ratio (-18%) and percent contribution of vastus medialis to experimental torque (- 24%) was observed pre- to post- hypertonic injection. No differences were observed with isotonic injections, confirming the validity of the model. Interpretation: Our practical method to estimate strength ratios can be easily implemented within a musculoskeletal modeling framework to improve the validity of model estimates. This, in turn, can increase our understanding of the relationship between neuromuscular deficits and functional outcomes in patient populations.
机译：背景：Quadriceps肌肉组的自愿活化缺陷是膝关节损伤的群体中的常见症状。肌肉骨骼建模和模拟可以提高我们对病理条件的理解;然而，它们是数学上的复杂，其可以限制其临床应用。引入了一个实际的主题特定建模框架，以评估膝关节延长抑制和肌肉力贡献，在健康成年人中的等距膝关节扭矩，没有通过实验诱导的Quadriceps肌肉疼痛。方法：使用随机交叉安慰剂控制研究设计。来自13名未受吸收的年轻成人的主题特定最大膝关节延长扭矩和Quadriceps电拍摄数据在建模框架中组合在建模框架中，以确定最佳的肌肉强度缩放参数和理想的扭矩。在肌肉内高渗（疼痛诱导）和等渗（假）盐水中以前和实验扭矩的强度缺陷比（实验扭矩/理想扭矩）和单个肌肉贡献被注射到墨水中的异肌。结果：观察到实验膝关节延长扭矩（ - 8％）和夸张的肌动画（ - 26％）振幅预先检测。相应地，膝关节延长强度缺陷比（-18％）的显着降低和夸张的术中对实验扭矩（ - 24％）的百分比百分比被检测到后高渗注射。使用等渗注射没有观察到差异，确认模型的有效性。解释：我们的实际方法可以在肌肉骨骼建模框架内轻松实现估计强度比，以提高模型估计的有效性。反过来，这可以提高我们对患者群体中神经血清缺陷和功能结果之间的关系的理解。

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