A New CYP3A5*3 and CYP3A4*22 Cluster Influencing Tacrolimus Target Concentrations: A Population Approach

Andreu Franc; Colom Helena; Elens Laure; van Gelder Teun; van Schaik Ronald H. N.; Hesselink Dennis A.; Bestard Oriol; Torras Joan; Cruzado Josep M.; Grinyo Josep M.; Lloberas Nuria

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A New CYP3A53 and CYP3A422 Cluster Influencing Tacrolimus Target Concentrations: A Population Approach

机译：一种新的CYP3A5 * 3和CYP3A4 * 22集群，影响他克莫士群目标浓度：人口方法

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Background Single nucleotide polymorphisms (SNPs) in the CYP3A5 and CYP3A4 genes have been reported to be an important cause of variability in the pharmacokinetics of tacrolimus in renal transplant patients. The aim of this study was to merge all of the new genetic information available with tacrolimus pharmacokinetics to generate a more robust population model with data from renal transplant recipients. Methods Tacrolimus exposure data from 304 renal transplant recipients were collected throughout the first year after transplantation and were simultaneously analyzed with a population pharmacokinetic approach using NONMEMA (R) version 7.2.

机译：据报道，CYP3A5和CYP3A4基因中的单核苷酸多态性（SNP）是肾移植患者中标司司的药代动力学变异性的重要原因。本研究的目的是将所有新的遗传信息合并了他克莫司药代动力学可获得的所有新的遗传信息，以产生更强大的人口模型，其中来自肾移植受者的数据。方法在移植后的第一年内收集来自304个肾移植受体的Tacrolimus暴露数据，并使用Nonmema版本7.2分析了群体药代动力学方法的分析。

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《Clinical pharmacokinetics》 |2017年第8期|共13页
作者
Andreu Franc; Colom Helena; Elens Laure; van Gelder Teun; van Schaik Ronald H. N.; Hesselink Dennis A.; Bestard Oriol; Torras Joan; Cruzado Josep M.; Grinyo Josep M.; Lloberas Nuria;
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作者单位

Univ Barcelona Nephrol Serv Lab 4122 Campus Bellvitge Pavello Govern Feixa Llarga S-N Barcelona;

Univ Barcelona Sch Pharm Dept Pharm Biopharmaceut &

Pharmacokinet Unit Barcelona Spain;

UCL LDRI Dept Integrated PharmacoMetr PharmacoGen &

Pharma Brussels Belgium;

Univ Med Ctr Erasmus MC Dept Internal Med Rotterdam Netherlands;

Univ Med Ctr Erasmus MC Dept Hosp Pharm Rotterdam Netherlands;

Univ Med Ctr Erasmus MC Dept Internal Med Rotterdam Netherlands;

Univ Barcelona Nephrol Serv Lab 4122 Campus Bellvitge Pavello Govern Feixa Llarga S-N Barcelona;

Univ Barcelona Nephrol Serv Lab 4122 Campus Bellvitge Pavello Govern Feixa Llarga S-N Barcelona;

Univ Barcelona Nephrol Serv Lab 4122 Campus Bellvitge Pavello Govern Feixa Llarga S-N Barcelona;

Univ Barcelona Nephrol Serv Lab 4122 Campus Bellvitge Pavello Govern Feixa Llarga S-N Barcelona;

Univ Barcelona Nephrol Serv Lab 4122 Campus Bellvitge Pavello Govern Feixa Llarga S-N Barcelona;

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正文语种 eng
中图分类药理学;
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1. A New CYP3A5*3 and CYP3A4*22 Cluster Influencing Tacrolimus Target Concentrations: A Population Approach [J] . Andreu Franc, Colom Helena, Elens Laure, Clinical pharmacokinetics . 2017,第8期

机译：一种新的CYP3A5 * 3和CYP3A4 * 22集群，影响他克莫士群目标浓度：人口方法
2. Effect of CYP3A4*22 and CYP3A4*1B but not CYP3A5*3 polymorphisms on tacrolimus pharmacokinetic model in Tunisian kidney transplant [J] . Hannachi Ibtissem, Ben Fredj Nadia, Chadli Zohra, Toxicology and Applied Pharmacology . 2020,第1期

机译：CYP3A4 * 22和CYP3A4 * 1B但不是CYP3A5 * 3多态性在突尼斯肾移植中的CYP3A5 * 3多态性
3. CYP3A5 genotype, but not CYP3A4*1b, CYP3A4*22, or hematocrit, predicts tacrolimus dose requirements in Brazilian renal transplant patients [J] . SantoroA.B., StruchinerC.J., FelipeC.R., Clinical Pharmacology and Therapeutics . 2013,第2期

机译：CYP3A5基因型而非CYP3A4 * 1b，CYP3A4 * 22或血细胞比容可预测巴西肾移植患者的他克莫司剂量需求
4. Influence of CYP3A5 polymorphism on tacrolimus blood concentrations in renal transplant patients [C] . NIE Xin-min, GUI Rong, ZHAO Hong-shan, Postdoctoral Symposium for Celebration of 20th Anniversary of the Foundation of Chinese Postdoctoral System; 2005; . 2005

机译：CYP3A5基因多态性对肾移植患者他克莫司血药浓度的影响
5. Clustered Integrin Ligands as a Novel Approach for the Targeting of Non-Viral Vectors. [D] . Ng, Quinn Kwan Tai. 2010

机译：聚集整联蛋白配体作为一种针对非病毒载体的新型方法。
6. Effect of CYP3A4*22 CYP3A5*3 and CYP3A Combined Genotypes on Cyclosporine Everolimus and Tacrolimus Pharmacokinetics in Renal Transplantation [O] . D J A R Moes, J J Swen, J den Hartigh, 2014

机译：CYP3A4 * 22CYP3A5 * 3和CYP3A联合基因型对肾移植中环孢霉素依维莫司和他克莫司药代动力学的影响
7. Tacrolimus Elimination in Four Patients With aCYP3A5*3/*3 CYP3A4*22/*22Genotype Combination [O] . Aileen Scheibner, Rory Remmel, David Schladt, 2018

机译：四个患者ACYP3A5 * 3 / * 3 CYP3A4 * 22 / * 22总根型组合中的Tacrolimus消除
8. Population Pharmacokinetic Modeling Approach Shows that Serum Penicillin G Concentrations Are Below Inhibitory Concentrations by Two Weeks after Benzathine Penicillin G Injection in the Majority of Young Adults. [R] . Neely, M., Kaplan, E. L., Blumer, J. L., 2014

机译：群体药代动力学模型方法显示，在大多数青少年中注射苯甲西林青霉素G后，血清青霉素G浓度低于抑制浓度两周。

A New CYP3A5*3 and CYP3A4*22 Cluster Influencing Tacrolimus Target Concentrations: A Population Approach

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A New CYP3A53 and CYP3A422 Cluster Influencing Tacrolimus Target Concentrations: A Population Approach