Ovarian Cancer Prevention in High-risk Women

SARAH M. TEMKIN; JENNIFER BERGSTROM; GOLI SAMIMI; LORI MINASIAN

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Ovarian Cancer Prevention in High-risk Women

机译：高危女性卵巢癌预防

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Ovarian carcinoma is the most lethal malignancy of the female genital tract. Population-based trials in the general population have not demonstrated that screening improves early detection or survival. Therefore, application of prevention strategies is vital to improving outcomes from this disease. Surgical prevention reduces risk and prophylactic risk-reducing salpingo-oophorec- tomy is the most effective means to prevent ovarian carcinoma in the high-risk patient although the risks do not outweigh the benefits in average risk patients. Other surgical and medical options have unknown or limited efficacy in the high-risk patient. In this review, we define the patient at high risk for ovarian cancer, discuss how to identify these women and weigh their available ovarian cancer prevention strategies.

机译：卵巢癌是女性生殖道最致命的恶性肿瘤。一般人群的基于人口的试验尚未表明筛查改善早期检测或存活。因此，预防策略的应用对于改善这种疾病的结果至关重要。手术预防降低风险和预防性降低的降温Salpingo-Oophorec-Tomy是预防高危患者卵巢癌的最有效手段，尽管风险不会超过平均风险患者的益处。其他手术和医疗选择在高风险患者中具有未知或有限的疗效。在这篇综述中，我们以高风险定义卵巢癌的患者，讨论如何识别这些女性并称重其可用的卵巢癌预防策略。

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来源
《Clinical Obstetrics and Gynecology》 |2017年第4期|共20页
作者
SARAH M. TEMKIN; JENNIFER BERGSTROM; GOLI SAMIMI; LORI MINASIAN;
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作者单位

Department of Obstetrics and Gynecology Virginia Commonwealth University Richmond Virginia;

Johns Hopkins School of Medicine Kelly Gynecologic Oncology Service Baltimore Maryland;

Division of Cancer Prevention National Cancer Institute Bethesda Maryland;

Division of Cancer Prevention National Cancer Institute Bethesda Maryland;

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原文格式 PDF
正文语种 eng
中图分类妇产科学;
关键词
ovarian cancer prevention; BRCA; risk- reducing surgery;

机译：卵巢癌预防;BRCA;风险降低手术;

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专利

1. Ovarian Cancer Prevention in High-risk Women [J] . SARAH M. TEMKIN, JENNIFER BERGSTROM, GOLI SAMIMI, Clinical Obstetrics and Gynecology . 2017,第4期

机译：高危女性卵巢癌预防
2. The Prevalence of Ovarian Cancer in Korean Women at High-Risk for Hereditary Breast-Ovarian Cancer [J] . Lee Jihyoun, Kang Eunyoung, Kim Sung-Won, Journal of Breast Cancer . 2011,第Suppla1期

机译：韩国女性遗传性乳腺卵巢癌高发人群中的卵巢癌患病率
3. Targeted surgical prevention of epithelial ovarian cancer is cost effective and saves money in BRCA mutation carrying family members of women with epithelial ovarian cancer. A Canadian model [J] . Hoskins Paul, Eccleston Anthony, Hurry Manjusha, Gynecologic Oncology: An International Journal . 2019,第1期

机译：针对上皮性卵巢癌的靶向外科预防是成本效益，并在BRCA突变携带上皮卵巢癌的妇女家庭成员中储蓄。加拿大模型
4. The Application of Computed Tomography in the Prevention of Ovarian Cancer [C] . Lihong Bao International Conference on Applied Science and Engineering Innovation . 2015

机译：计算断层扫描在预防卵巢癌中的应用
5. Ovarian Cancer Metabolism: Effect of Anoikis Condition and Nitric Oxide on Ovarian Cancer Metabolism, and Effect of Metabolites on Ovarian Cancer Migration [D] . Caneba, Christine Ann. 2013

机译：卵巢癌代谢：厌食症和一氧化氮对卵巢癌代谢的影响，以及代谢产物对卵巢癌迁移的影响
6. Prophylactic Bilateral Salpingectomy as a Prevention Strategy in Women at High-Risk of Ovarian Cancer: A Mini-Review [O] . Tess Schenberg, Gillian Mitchell 2014

机译：预防性双侧输卵管切除术作为卵巢癌高发女性的预防策略：综述。
7. Prophylactic Bilateral Salpingectomy as a Prevention Strategy in Women at High-Risk of Ovarian Cancer: A Mini-Review [O] . Tess Schenberg, Gillian Mitchell 2014

机译：预防性双侧输卵管切除术作为高风险卵巢癌女性的预防策略：一个小型评论
8. Role of Angiogenesis in the Etiology and Prevention of Ovarian Cancer. 4. Prevention of Ovarian Carcinoma Dissemination by Inhibiting Cell Adhesion [R] . Ramakrishnan, S. 2003

机译：血管生成在卵巢癌病因和预防中的作用。 4.通过抑制细胞粘附来预防卵巢癌的传播

Ovarian Cancer Prevention in High-risk Women

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