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首页> 外文期刊>Clinics in dermatology >Protecting people against leprosy: Chemoprophylaxis and immunoprophylaxis
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Protecting people against leprosy: Chemoprophylaxis and immunoprophylaxis

机译：保护人们对抗麻风病：化学脑膜和免疫营养素

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Elimination of leprosy cannot be achieved by multidrug therapy alone, and new tools are needed to prevent leprosy. A randomized controlled trial with chemoprophylaxis for contacts of leprosy patients using a single dose of rifampicin (SDR) has shown an overall protective effect of approximately 60%, effective in the first 2 years after the intervention. When a contact who previously received bacillus Calmette-Guerin (BCG) vaccination also receives SDR, the protective effect is additive, approximating 80%. Vaccine trials have been conducted with BCG, often in combination with Mycobacterium leprae or related Mycobacterium vaccines as immunoprophylaxis for contacts of leprosy patients, with BCG giving the best results. Meta-analysis shows that the protective effect of BCG vaccination is larger in observational studies than in trials, 60% versus 41%, and is higher among contacts of leprosy patients than among the general population, 68% versus 53%. We believe that a future leprosy control strategy should include contact management, consisting of a contact survey, at which time preventive interventions could be added, such as chemoprophylaxis and immunoprophylaxis. Modeling studies have shown that both interventions will lower the incidence of leprosy in the population. Implementation studies of such contact-based strategy are now called for. (C) 2015 Elsevier Inc. All rights reserved.
机译：通过单独的多药治疗不能实现麻风病，并且需要进行新工具来防止麻风病。使用单剂量利福平（SDR）的随机对照试验，用于使用单剂量的利福平（SDR）的麻风病患者的联系，已经显示出约60％的整体保护作用，在干预后的前2年中有效。当前接受芽孢杆菌患者的联系人接种疫苗接种疫苗接种时，保护效果是添加剂，近似80％。疫苗试验已经用BCG进行，通常与皮杆菌或相关的分枝杆菌疫苗与麻风病患者接触的免疫蛋白质相结合，并具有BCG的效果。荟萃分析表明，在观察研究中，BCG疫苗接种的保护作用比试验在试验中较大，60％对41％，并且麻风病患者的触点比一般人群相比，68％与53％相比。我们认为，未来的麻风感控制策略应包括联系人管理，由接触调查组成，此时可以添加预防性干预措施，例如化学缺口和免疫营养素。建模研究表明，两种干预措施都会降低人口中麻风病的发生率。现在呼吁这种基于接触策略的实施研究。 （c）2015 Elsevier Inc.保留所有权利。

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