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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Inhibitory Killer Immunoglobulin-like receptors to self HLA-B and HLA-C ligands contribute differentially to Natural Killer cell functional potential in HIV infected slow progressors
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Inhibitory Killer Immunoglobulin-like receptors to self HLA-B and HLA-C ligands contribute differentially to Natural Killer cell functional potential in HIV infected slow progressors

机译：自身HLA-B和HLA-C配体的抑制杀手免疫球蛋白样受体差异为HIV感染缓慢进展中的天然杀伤细胞功能潜力差异

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摘要

Inhibitory Killer Immunoglobulin-like Receptors (iKIR) interact with their ligands, HLA molecules, to license Natural Killer (NK) cells for functional competence. Previous studies stimulating peripheral blood mononuclear cells (PBMCs) with the HLA-devoid K562 cell line revealed that NK cells from individuals with an iKIR encoded by the KIR3DL1 locus with self HLA-Bw4 as their ligands, had higher frequencies of tri-functional NK cells that expressed the degranulation marker CD107a and secreted Interferon-γ and Tumor Necrosis Factor-α than those from individuals who were homozygous for HLA-Bw6 alleles, which are not ligands for these iKIR. To assess the effect of other iKIR to self-HLA (S-iKIR) on the NK cell response, we compared HIV-infected slow progressors (SP) carrying S-iKIR to HLA-C alleles with or without S-iKIR to HLA-Bw4. We show that S-iKIR to HLA-B and C alleles differ in their contribution to NK cell functional potential in HIV-infected SP upon stimulation with K562 targets.
机译：抑制杀手免疫球蛋白样受体（IKIR）与其配体HLA分子相互作用，使许可自然杀伤（NK）细胞用于功能能力。以前的研究刺激外周血单核细胞（PBMC）与HLA-Demoid K562细胞系显示，来自具有由Kir3Dl1基因座的IKIR中的个体具有自身HLA-BW4作为它们的配体的单独的NK细胞具有较高的三官能NK细胞频率表达脱粒标志物CD107a和分泌的干扰素-γ和肿瘤坏死因子-α，与HLA-BW6等位基因纯合的个体，这不是这些IKIR的配体。为了评估其他IKIR对自我HLA（S-IKIR）对NK细胞反应的影响，我们将艾滋病毒感染的缓慢进展（SP）与HLA-C携带的HLA-C等位基因进行比较，或者没有S-IKIR到HLA- BW4。我们表明，在用K562靶标刺激时，S-IKIR至HLA-B和C等位基因对HIV感染的SP中的NK细胞功能潜力的贡献不同。

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    KamyaP.; TallonB.; Melendez-PenaC.; ParsonsM.S.; MiguelesS.A.; ConnorsM.; MiconiatisS.; SongR.; BouletS.; BruneauJ.; TremblayC.L.; BernardN.F.;

  • 作者单位

    Research Institute of the McGill University Health Centre Montréal QC Canada Division of;

    Research Institute of the McGill University Health Centre Montréal QC Canada Division of;

    Research Institute of the McGill University Health Centre Montréal QC Canada Division of;

    Research Institute of the McGill University Health Centre Montréal QC Canada Division of;

    National Institutes of Allergy and Infectious Diseases National Institutes of Health Bethesda MD;

    National Institutes of Allergy and Infectious Diseases National Institutes of Health Bethesda MD;

    Research Institute of the McGill University Health Centre Montréal QC Canada Division of;

    Research Institute of the McGill University Health Centre Montréal QC Canada Division of;

    Maisonneuve-Rosemont Hospital Research Center Department of Microbiology and Immunology;

    Centre de Recherche du Centre Hospitalier de l'Université de Montréal Montréal QC Canada;

    Centre de Recherche du Centre Hospitalier de l'Université de Montréal Montréal QC Canada;

    Research Institute of the McGill University Health Centre Montréal QC Canada;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学免疫学;
  • 关键词

    HLA-ligands; Killer-Immunoglobulin-like Receptors; Natural Killer (NK) cells; NK function;

    机译：HLA-配体;杀手 - 免疫球蛋白样受体;天然杀伤（NK）细胞;NK功能;

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