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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Dysregulated Tim-3 expression and its correlation with imbalanced CD4 helper T cell function in ulcerative colitis
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Dysregulated Tim-3 expression and its correlation with imbalanced CD4 helper T cell function in ulcerative colitis

机译：溃疡性结肠炎中溃疡性CON-Helper T细胞功能的表现令人医学的TIM-3表达及其相关性

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摘要

The pathogenesis of ulcerative colitis (UC) remains largely unclear. Here we found that T-cell Ig mucin-3 (Tim-3) and its ligand, galectin 9 (Gal-9), were significantly decreased in UC patients and in mice with dextran sodium sulfate (DSS)-induced colitis compared to controls. In addition to an enhanced Th17 response and attenuated regulatory T (Treg) cell response, there was also a significantly decreased Th1 response in UC. Levels of the Th1 cell chemokines CXCL9 and CXCL10 were significantly decreased in UC mice, partially explaining the decreased Th1 cell function in UC. Finally, administration of a putative antagonistic anti-Tim-3 antibody or of recombinant Gal-9 significantly exacerbated or attenuated DSS-induced colitis by altering the balance between different Th cell subsets. Our data suggest that a dysregulated Tim-3/Gal-9 pathway may contribute to the pathogenesis of UC. A better understanding of this pathway may shed new light on the pathogenesis of this disease.
机译：溃疡性结肠炎（UC）的发病机制仍然很大程度上不清楚。 在这里，我们发现在UC患者和用葡聚糖硫酸钠（DSS）诱导的结肠炎的小鼠中，T细胞IG粘蛋白-3（TIM-3）及其配体，Galectin 9（Gal-9）显着降低 。 除了增强的Th17反应和减毒的调节性T（Treg）细胞反应之外，UC中还存在显着降低的Th1响应。 在UC小鼠中，TH1细胞趋化因子CXCL9和CXCL10的水平显着降低，部分解释了UC中的降低的Th1细胞功能。 最后，通过改变不同TH细胞亚群之间的平衡来施用推定的拮抗抗-iM-3抗体或重组GAL-9显着恶化或减弱DSS诱导的结肠炎。 我们的数据表明，失调的TIM-3 / GAL-9途径可能有助于UC的发病机制。 更好地了解这条途径可能对这种疾病的发病机制揭示了新的光线。

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    ShiF.; GuoX.; JiangX.; ZhouP.; XiaoY.; ZhouT.; ChenG.; ZhaoZ.; XiaoH.; HouC.; LiX.; YangX.; WangR.; FengJ.; ShenB.; LiY.; HanG.;

  • 作者单位

    Department of Molecular Immunology Institute of Basic Medical Sciences Beijing 100850 China;

    Department of Molecular Immunology Institute of Basic Medical Sciences Beijing 100850 China;

    Department of Molecular Immunology Institute of Basic Medical Sciences Beijing 100850 China;

    Department of Gastroenterology General Hospital of the Air Force of China Beijing 100142 China;

    Department of Respiratory Medicine First Affiliated Hospital of the Chinese PLA General Hospital;

    Department of Molecular Immunology Institute of Basic Medical Sciences Beijing 100850 China;

    Department of Molecular Immunology Institute of Basic Medical Sciences Beijing 100850 China;

    Department of Molecular Immunology Institute of Basic Medical Sciences Beijing 100850 China;

    Department of Molecular Immunology Institute of Basic Medical Sciences Beijing 100850 China;

    Department of Molecular Immunology Institute of Basic Medical Sciences Beijing 100850 China;

    Department of Molecular Immunology Institute of Basic Medical Sciences Beijing 100850 China;

    Department of Molecular Immunology Institute of Basic Medical Sciences Beijing 100850 China;

    Department of Molecular Immunology Institute of Basic Medical Sciences Beijing 100850 China;

    Department of Molecular Immunology Institute of Basic Medical Sciences Beijing 100850 China;

    Department of Molecular Immunology Institute of Basic Medical Sciences Beijing 100850 China;

    Department of Molecular Immunology Institute of Basic Medical Sciences Beijing 100850 China;

    Department of Molecular Immunology Institute of Basic Medical Sciences Beijing 100850 China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学免疫学;
  • 关键词

    Gal-9; Immune regulation; T help cells; Tim-3; Ulcerative colitis;

    机译：GAL-9;免疫调节;T帮助细胞;TIM-3;溃疡性结肠炎;

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