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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Autoantibodies, detection methods and panels for diagnosis of Sj?gren's syndrome
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Autoantibodies, detection methods and panels for diagnosis of Sj?gren's syndrome

机译：用于诊断SJ的自身抗体，检测方法和面板？GREN的综合征

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Abstract The presence of autoantibodies is one of several hallmarks of Sj?gren's Syndrome, the detection of serum autoantibodies has a central role in the diagnosis and classification of Sj?gren's syndrome. In this review, we will discuss autoantibodies that are helpful in the diagnosis of Sj?gren's syndrome. This includes the traditional autoantibodies for disease classification (ANA, Anti-Ro/SSA, Anti-La/SSB, RF), autoantibodies identified from mouse models (Anti-SP1, Anti- PSP, Anti-CA6, and anti-alpha fodrin) and autoantibodies associated with other autoimmune disease (ACA, AMA, and Anti-CCP). We will also review the methods for the detection of autoantibodies and associated challenges for clinical results reporting. The significance of using an autoantibody panel for the diagnosis of SS will be also be reviewed. Highlights ? Detection of serum autoantibodies play a central role in the diagnosis and classification of Sj?gren’s Syndrome. ? Autoantibodies that are helpful in the diagnosis of Sj?gren’s syndrome were reviewed. ? This includes the traditional autoantibodies for disease classification (ANA, Anti-Ro/SSA, Anti-La/SSB, RF). ? Autoantibodies identified from mouse models (Anti-SP1, Anti- PSP, Anti-CA6, and anti-alpha fodrin). ? Autoantibodies associated with other autoimmune disease (ACA, AMA, and Anti-CCP). ? Methods for the detection of autoantibodies and associated challenges for clinical results reporting were reviewed. ? The significance of using an autoantibody panel for the diagnosis of SS was reviewed.
机译：摘要Auto intibodies的存在是SJ的几个标志之一？GREN的综合征，检测血清自身抗体在SJ的诊断和分类中具有核心作用。GREN的综合征。在这篇综述中，我们将讨论有助于诊断SJ的自身抗体？GREN的综合征。这包括传统的疾病分类自身抗体（ANA，抗RO / SSA，抗LA / SSB，RF），来自小鼠模型的自身抗体（抗SP1，抗PSP，抗CA6和抗-αFodrin）与其他自身免疫性疾病（ACA，AMA和ANT-CCP​​相关的自身抗体。我们还将审查检测自身抗体和相关挑战对临床结果报告的方法。还将审查使用自身抗体面板进行SS诊断的重要性。强调 ？检测血清自身抗体在SJ的诊断和分类中起着核心作用。还有助于诊断SJ的自身抗体进行审查。审查了GREN的综合症。还这包括传统的疾病分类自身抗体（ANA，抗RO / SSA，抗LA / SSA，RF）。还从小鼠模型（抗SP1，抗PSP，抗CA6和抗αFODRIN）鉴定的自身抗体。还与其他自身免疫性疾病（ACA，AMA和ANT-CCP​​相关的自身抗体。还综述了检测自身抗体和相关挑战的方法进行了综述。还综述了使用自身抗体面板进行SS诊断的重要性。

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