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首页> 外文期刊>Clinical drug investigation >Clinical Characteristics of Japanese Patients with Palmoplantar Pustulosis
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Clinical Characteristics of Japanese Patients with Palmoplantar Pustulosis

机译：日本棕榈术脓疱病患者的临床特征

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摘要

Palmoplantar pustulosis (PPP) is a chronic inflammatory disorder characterized by sterile pustules predominantly involving the palms and soles. The purpose of this review was to describe the characteristics of Japanese PPP patients as PPP is frequently observed within the Japanese population. Most Japanese dermatologists consider PPP a distinct entity, and co-existence of PPP and psoriasis is rare; however, outside Japan, PPP is often considered to be palmoplantar psoriasis, and an extra-palmoplantar lesion associated with PPP is considered to be psoriasis. PPP frequently develops or exacerbates following focal infections such as tonsillitis, odontogenic infection, and sinusitis, either with or without arthralgia. Pustulotic arthro-osteitis (PAO) is a major comorbidity of PPP, most often affecting the anterior chest wall. In Japanese patients, PAO is frequently seen, whereas cases of SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome with symptoms other than PPP and sternocostoclavicular joint pain are extremely rare. A difference in incidence depending on race suggests that different genetic backgrounds may be responsible for susceptibility to these disorders. The treatment of focal infections often results in dramatic effects on cutaneous lesions, as well as joint pain. The characteristics of Japanese patients with PPP are female predominance, mostly smokers, rare co-existence with psoriasis, frequent association with PAO, almost no accompanying celiac disease, and closely associated with focal infection. PPP should be separately considered from palmoplantar psoriasis.
机译：棕榈叶腭裂（PPP）是一种慢性炎症性疾病，其特征在于主要涉及棕榈树和鞋底的无菌脓液。本评价的目的是描述日本PPP患者的特征，因为PPP经常在日本人口中观察到。大多数日本皮肤科医生认为PPP一个不同的实体，PPP和牛皮癣的共存是罕见的;然而，在日本以外，PPP通常被认为是棕榈脑牛皮癣，并且与PPP相关的超棕榈叶病变被认为是牛皮癣。 PPP经常在局灶性感染之类的圆锥细胞炎，幼儿发生感染和鼻窦炎之后发育或加剧，无论是在还是没有关节痛。脓疱疮 - 骨炎（PAO）是PPP的主要合并症，最常影响前胸壁。在日本患者中，PAO经常被人看到，而Sapho（滑膜炎，痤疮，粉丝，过度症，骨炎）综合征，症状与PPP和胸骨菌菌关节疼痛以外的症状非常罕见。根据种族的发病率差异表明，不同的遗传背景可能负责对这些疾病的易感性。局灶性感染的治疗往往导致皮肤病变的显着影响，以及关节疼痛。日本PPP患者的特点是女性优势，大多数吸烟者，罕见的牛皮癣共存，与PAO频繁联系，几乎没有伴随乳糜泻，并且与焦点感染密切相关。 PPP应单独考虑来自棕榈植物牛皮癣。

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