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首页> 外文期刊>Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) >Auditory P300 as a Neurophysiological Correlate of Symptomatic Improvement by Transcranial Direct Current Stimulation in Patients With Schizophrenia: A Pilot Study
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Auditory P300 as a Neurophysiological Correlate of Symptomatic Improvement by Transcranial Direct Current Stimulation in Patients With Schizophrenia: A Pilot Study

机译：听觉P300作为精神分裂症患者经颅直流刺激的症状改善的神经生理相关性：试点研究

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Background. The reduced amplitude, prolonged latency, and increased intertrial variability of auditory P300 have been consistently reported in relation to the symptomatic severity of schizophrenia. This study investigated whether auditory P300 event-related potentials can be used as an objective indicator of symptomatic improvement by transcranial direct current stimulation (tDCS) in patients with schizophrenia.Methods. Ten patients with schizophrenia received 20 minutes of 2-mA tDCS twice a day for 5 consecutive weekdays. The anode was placed over the left dorsolateral prefrontal cortex, and the cathode was placed over the left temporo-parietal cortex. The Positive and Negative Syndrome Scale (PANSS) and the auditory P300 were measured for each participant at baseline and after the completion of the tDCS applications.Results. The participants showed significant improvement in the positive and negative symptoms as indexed by change in the PANSS scores by the tDCS. The P300 amplitude, latency, and intertrial variability did not statistically significantly differ after the tDCS application. However, a significant association was observed between the reduced P300 intertrial variability and improvement in the positive symptoms by tDCS. In addition, the changes in both the P300 latency and intertrial variability were significantly correlated with reduced negative symptoms after the tDCS application.Conclusions. Although this pilot study is limited by the small sample size and lack of a sham control, the results suggest that auditory P300 may be a putative marker reflecting the effect of tDCS on the positive and negative symptoms of schizophrenia.
机译：背景。关于精神分裂症的症状严重程度，一直报道了降低的幅度，延长延迟和闭合性变异性。本研究调查了听觉P300的事件相关电位是否可用作精神分裂症患者患者经颅直流刺激（TDCS）作为症状改善的客观指标。方法。 10例精神分裂症患者每天每天两次接受20分钟的2 mA TDCs。将阳极放在左侧背侧前额叶皮质上，将阴极置于左颞下皮层上。对基线的每个参与者和TDCS应用程序完成后，测量正面和负综合征秤（平底锅）和听觉P300。结果。参与者显示出通过TDC的粉丝分数的变化所指的正面和消极症状的显着改善。在TDCS应用后，P300幅度，延迟和闭层变异性在统计学上没有显着差异。然而，通过TDCs降低的P300闭合性变异性和改善阳性症状之间观察到显着关联。此外，P300潜伏期和闭层变异的变化与TDCS应用后的阴性症状减少显着相关。结论。尽管该试点研究受到小样本大小和缺乏假手术的限制，但结果表明，听觉P300可能是一种推定标记，反映了TDC对精神分裂症的正面和阴性症状的影响。

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