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A pilot study investigating the effect of transcranial direct current stimulation on the electrophysiological correlates of working memory in patients with schizophrenia

机译:试验研究调查经颅直流刺激对精神分裂症患者工作记忆电生理相关性的影响

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摘要

Transcranial direct current stimulation (tDCS) exerts pro-cognitive effects in various populations. We evaluated the effect of tDCS on cognitive performance and its electrophysiological correlates in schizophrenia patients. Ten participants received 10 sessions of tDCS and performed cognitive performance tasks; error-related negativity and correct response negativity (CRN) were measured before and after tDCS. Verbal performance was improved by tDCS and strongly correlated with a reduced CRN amplitude. Despite the lack of sham control design and possible practice effects of cognitive tasks, we might conclude that CRN could be a modifiable electrophysiological correlate of cognitive improvement by tDCS.
机译:经颅直流刺激(TDCS)在各种群体中施加亲认知效果。 我们评估了TDC对精神分裂症患者的认知性能及其电生理学相关性的影响。 十名参与者收到了10个TDC会议,并执行了认知性能任务; 在TDCS之前和之后测量误差相关的消极性和正确的响应消极性(CRN)。 TDCs改善了口头表现,并与减少的CRN幅度强烈相关。 尽管缺乏虚假控制设计和认知任务的可能实践效果,但我们可能会得出结论,CRN可以是通过TDC的认知改善的可修改的电生理相关性。

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