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首页> 外文期刊>Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) >Levodopa Reduces the Phase lag Index of Parkinson's Disease Patients: A Magnetoencephalographic Study
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Levodopa Reduces the Phase lag Index of Parkinson's Disease Patients: A Magnetoencephalographic Study

机译：Levodopa降低了帕金森病患者的阶段滞后指数：磁性肺体研究

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Objectives. As a method of measuring the phase difference between 2 signals, the phase lag index (PLI) of the alpha and beta bands in patients with Parkinson's disease (PD) was investigated by using magnetoencephalography (MEG). Methods. Eighteen PD patients were measured by MEG in the state of overnight withdrawal of levodopa and after levodopa treatment; meanwhile, Unified Parkinson's Disease Rating Scale (UPDRS) III scale was evaluated. Results. Compared with healthy controls, alpha (8-13 Hz) PLI in the frontal and parietal areas elevated in PD patients, while the elevation was reversed by the levodopa treatment. The alterations of the UPDRS III total scale (r(s) = 0.552, P = .013, n = 16) and the changes of akinesia scale (r(s) = 0.622, P = .005, n = 16) were correlated to the change of beta (13-30 Hz) PLI in the left parietal area. The change of the UPDRS total scale was negatively correlated to duration of disease (r(s) = 0.432, P = .047, n = 16). There was a negative correlation between the age of PD patients and the change of alpha PLI in the left frontal area (r(s) = 0.519, P = .020, n = 16). Conclusions. PD patients showed a higher mu PLI in the sensorimotor area relative to the healthy controls. The improvement of motor symptoms of PD patients by levodopa was correlated to the inhibition of beta PLI in the sensorimotor area.
机译：目标。作为测量2个信号之间的相位差的方法，通过使用磁性脑图（MEG）研究了帕金森病（PD）患者中α和β带的相滞率（PLI）。方法。在左旋多巴和左旋多巴治疗后，通过MEG测量18名PD患者。同时，评估了统一的帕金森的疾病评级规模（UPDRS）III规模。结果。与健康对照相比，在PD患者中升高的前部和顶部区域中的α（8-13Hz）PLI，而左泊帕治疗升高升高。 updrs III总尺度的改变（R（s）= 0.552，p = .013，n = 16）和αkinesia刻度的变化（r（s）= 0.622，p = .005，n = 16）是相关的在左翼面积中的β（13-30 Hz）PLI的变化。 updrs总规模的变化与疾病持续时间呈负相关（r（s）= 0.432，p = .047，n = 16）。 PD患者的年龄与左正面区域中的αPLI的变化之间存在负相关性（R（s）= 0.519，p = .020，n = 16）。结论。 PD患者在感觉电池区域相对于健康对照表达了一个更高的MU PLI。通过左旋多巴的PD患者的电机症状的改善与感觉电池区域中βPLI的抑制相关。

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