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首页> 外文期刊>Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) >Contribution of Quantitative EEG to the Diagnosis of Early Cognitive Impairment in Patients With Idiopathic Parkinson's Disease
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Contribution of Quantitative EEG to the Diagnosis of Early Cognitive Impairment in Patients With Idiopathic Parkinson's Disease

机译：定量脑梗死与特发性帕金森病患者早期认知障碍诊断的贡献

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Cognitive dysfunction can emerge during the clinical course of Parkinson's disease (PD) even beginning in early stages, which requires extended neuropsychological tests for diagnosis. There is need for rapid, feasible, and practical tests in clinical practice to diagnose and monitor the patients without causing any discomfort. We investigated the utility of quantitative analysis of digital EEG (qEEG) for diagnosing subtle cognitive impairment in PD patients without evident cognitive deficits (ie, normal cognition). We enrolled 45 patients with PD and age- matched 39 healthy controls in the study. All participants had Mini-Mental State Examination (MMSE) score greater than 25. qEEG analysis and extensive neuropsychological assessment battery were applied to all participants. Test scores for frontal executive functions, verbal memory processes, attention span, and visuospatial functions were significantly lower than healthy controls (P < .01). qEEG analysis revealed a significant increase in delta, theta, and beta frequencies, and decrease in alpha frequency band in cerebral bioelectrical activity in patient group. In addition, power spectral ratios ([alpha + beta] / [delta + theta]) in frontal, central, temporal, parietal, and occipital regions were significantly decreased in patients compared with the controls. The slowing in EEG was moderately correlated with MMSE scores (r = 0.411-0.593; P < .01). However, qEEG analysis and extensive neuropsychological assessment battery were only in weak correlation (r = 0.230-0.486; P < .05). In conclusion, qEEG analysis could increase the diagnostic power in detecting subtle cognitive impairment in PD patients without evident cognitive deficit, perhaps years before the clinical onset of dementia.
机译：在帕金森病（PD）的临床过程中，可以出现认知功能障碍甚至从早期阶段开始，这需要延长神经心理学检验进行诊断。在临床实践中需要快速，可行和实际测试，以诊断和监测患者而不会引起任何不适。我们调查了数字脑电图（QEEG）的定量分析，以便在没有明显的认知缺陷（即正常认知）的情况下对PD患者进行微妙的认知障碍。我们注册了45名患有PD和患者的患者，在该研究中患有39例健康对照。所有参与者都有迷你精神状态检查（MMSE）得分大于25分。QEEG分析和广泛的神经心理学评估电池应用于所有参与者。正面执行功能的测试分数，口头记忆过程，注意力跨度和粘合性功能明显低于健康对照（P <.01）。 QEEG分析显示Delta，θ和β频率的显着增加，患者组中脑生物电活动中的α频带降低。另外，与对照相比，患者中额，中央，颞，颞，枕形和枕骨区域中的功率谱比（α+β/δ）显着降低。脑电图中的慢速与MMSE分数适度相关（r = 0.411-0.593; p <.01）。然而，QEEG分析和广泛的神经心理学评估电池仅在弱相关性（R = 0.230-0.486; p <.05）。总之，QEEG分析可能会增加PD患者在没有明显的认知缺陷的PD患者中检测微妙认知障碍的诊断能力，可能是痴呆症的临床发作前。

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