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首页> 外文期刊>Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) >Auditory Mismatch Negativity and P300a Elicited by the 'Optimal' Multi-feature Paradigm in Early Schizophrenia
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Auditory Mismatch Negativity and P300a Elicited by the 'Optimal' Multi-feature Paradigm in Early Schizophrenia

机译：在早期精神分裂症早期精神分裂症中的“最佳”多特征范例引发了听觉不匹配和P300A

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摘要

The mismatch negativity (MMN) is an EEG-derived event-related potential (ERP) elicited by any violation of a predicted auditory rule, regardless of whether one is attending to the stimuli and is thought to reflect updating of the stimulus context. Redirection of attention toward a rare, distracting stimulus event, however, can be measured by the subsequent P3a component of the P300. Chronic schizophrenia patients exhibit robust MMN deficits, as well as reductions in P3a amplitude. While, the substantial literature on the MMN in first-episode and early phase schizophrenia in this population reports reduced amplitudes, there also exist several contradictory studies. Conversely, P3a reduction in this population is relatively consistent, although the literature investigating this is small. The primary goal of this study was to contribute to our understanding of whether auditory change detection mechanisms are altered in early phase schizophrenia and, if so, under what conditions. Event-related potentials elicited by duration, frequency, gap, intensity, and location deviants (as elicited by the optimal multi-feature paradigm) were recorded in 14 early phase schizophrenia (EP) patients and 17 healthy controls (HCs). Electrical activity was recorded from 15 scalp electrodes. MMN/P3a amplitudes and latencies for each deviant were compared between groups and were correlated with clinical measures in EPs. There were no significant group differences for MMN amplitudes or latencies, though EPs did exhibit reduced P3a amplitudes to gap and duration deviants. Furthermore, PANSS (Positive and Negative Syndrome Scale) positive symptom scores were correlated with intensity MMN latencies and duration P3a amplitudes in EPs. These findings suggest that MMNs may not be as robustly reduced in early phase schizophrenia (relative to chronic illness), but that alterations may be more likely in patients with increased positive symptomatology. Furthermore, these findings offer further support to previous work suggesting that the understudied P3a may have good complementary utility as a marker of early cortical dysfunction in psychosis.
机译：不匹配的消极性（MMN）是由任何违反预测听觉规则引发的EEG推导的事件相关电位（ERP），无论是参加刺激，都被认为反映了刺激背景的更新。然而，通过P300的随后的P3a组分​​来测量罕见，分散注意力的刺激事件的重定向。慢性精神分裂症患者表现出强大的MMN缺陷，以及降低P3A幅度。虽然，在本群体中的第一集和早期精神分裂症中的MMN上的大量文献报告了降低幅度，但也存在几项矛盾研究。相反，P3a减少了这群人群相对一致，尽管调查这是小的。本研究的主要目标是有助于我们理解听觉改变检测机制是否在早期精神分裂症中改变，如果是的话，在什么条件下。在14项早期精神分裂症（EP）患者和17例健康对照（HCS）中，记录了持续时间，频率，间隙，强度和位置偏差（如最佳多特征范式所引发的潜力（如最佳多特征范式所引发的）引发的潜在潜力（如最佳多发性范式）。从15个头皮电极记录电活动。在组之间比较MMN / P3A幅度和延迟，并与EPS中的临床措施相关。 MMN幅度或延迟没有显着的组差异，但EPS表现出降低的P3a幅度到间隙和持续时间偏差。此外，平底锅（阳性和阴性综合征规模）阳性症状评分与EPS中的强度MMN延迟和持续时间P3A幅度相关。这些发现表明，早期精神分裂症（相对于慢性疾病）可能不那么稳健地降低，但随着阳性症状增加的患者可能更有可能更有可能更有可能。此外，这些调查结果为先前的工作提供了进一步的支持，表明被人工病症的早期皮质功能障碍的标志物具有良好的互补效用。

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