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首页> 外文期刊>Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) >Delta Brush Pattern Is Not Unique to NMDAR Encephalitis: Evaluation of Two Independent Long-Term EEG Cohorts
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Delta Brush Pattern Is Not Unique to NMDAR Encephalitis: Evaluation of Two Independent Long-Term EEG Cohorts

机译：Delta刷子图案不是NMDAR脑炎的独特之处：两个独立长期脑电图队的评估

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Purpose. Although its specificity has not previously been investigated in other cohorts, delta brush pattern (DBP) is increasingly reported in the EEGs of patients with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis. Methods. We aimed to investigate the DBP in the EEGs of 2 cohorts; patients with change in consciousness for various causes monitored in the intensive care unit (ICU) (n = 106) and patients with mesial temporal lobe epilepsy (MTLE) with or without antineuronal antibodies (n = 76). Results. These patients were investigated for the presence of DBP, defined as an EEG pattern characterized by delta activity at 1 to 3 Hz with superimposed bursts of rhythmic 12- to 30-Hz activity. Two investigators blindfolded for the clinical and immunological data independently analyzed the EEGs for recognition of this pattern. An EEG picture compatible with DBP was observed in 4 patients; only 1 of them (1.3%) belonged to the MTLE group. She did not bear any of the investigated autoantibodies and was seizure-free after epilepsy surgery. In the ICU group, there were 3 additional patients showing DBP with various diagnoses such as hypoxic encephalopathy, brain tumor, stroke, and metabolic derangements. All of them had died in 1-month period. Conclusions. Our results underlined that DBP is not unique to NMDAR encephalitis; it may very rarely occur in MTLE with good prognosis after surgery and second, in ICU patients who have high mortality rate. Therefore, the presence of this pattern should alert the clinician for NMDAR encephalitis but other possible etiologies should not be ignored.
机译：目的。尽管其特异性尚未在其他队列中进行调查，但在抗N-甲基-D-天冬氨酸受体（NMDAR）脑炎患者的脑梗死中越来越多地报道Delta刷子图案（DBP）。方法。我们旨在调查2个队列的脑电图的DBP;在重症监护单位（ICU）（ICU）（N = 106）中监测的各种原因变化的患者和有或没有抗脑尿抗体的患者颞叶癫痫（咒语）（n = 76）。结果。研究了这些患者的存在DBP，定义为以1至3Hz的δ活性为特征的EEG模式，其具有叠加的节奏12-至30Hz活性。两种针对临床和免疫数据蒙住眼睛的研究人员独立地分析了脑电图的脑电图以识别这种模式。在4名患者中观察到与DBP兼容的EEG图像;其中只有1个（1.3％）属于咒语组。她不承担任何调查的自身抗体，并在癫痫手术后没有癫痫发作。在ICU集团中，有3名患者显示DBP，各种诊断，如缺氧脑病，脑肿瘤，中风和代谢紊乱。所有这些都在1个月的时间里去世了。结论。我们的结果强调，DBP对NMDAR脑炎不是独一无二的;在手术后的预后良好的粪便中可能很少发生，并且在患有高死亡率的ICU患者中。因此，这种模式的存在应提醒临床医生对NMDAR脑炎，但不应忽视其他可能的病因。

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