Using Mismatch Negativity to Investigate the Pathophysiology of Substance Use Disorders and Comorbid Psychosis

Ramlakhan Jessica U.; Zomorrodi Reza; Downar Jonathan; Blumberger Daniel M.; Daskalakis Zafiris J.; George Tony P.; Kiang Michael; Barr Mera S.

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Using Mismatch Negativity to Investigate the Pathophysiology of Substance Use Disorders and Comorbid Psychosis

机译：使用不匹配的消极性来研究物质使用障碍和合并精神病症的病理生理学

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Substance use disorders (SUDs) have a devastating impact on society and place a heavy burden on health care systems. Given that alcohol, tobacco, and cannabis use have the highest prevalence, further understanding of the underlying pathophysiology of these SUDs is crucial. Electroencephalography is an inexpensive, temporally superior, and translatable technique which enables investigation of the pathobiology of SUDs through the evaluation of various event-related potential components, including mismatch negativity (MMN). The goals of this review were to investigate the effects of acute and chronic alcohol, tobacco, and cannabis use on MMN among nonpsychiatric populations and patients with comorbid psychosis. A literature search was performed using the database PubMed, and 36 articles met our inclusion and exclusion criteria. We found a pattern of attenuation of MMN amplitude among patients with alcoholism across acute and chronic alcohol use, and this dysregulation was not heritable. Reports were limited, and results were mixed on the effects of acute and chronic tobacco and cannabis use on MMN. Reports on comorbid SUDs and psychosis were even fewer, and also presented mixed findings. These preliminary results suggest that MMN deficits may be associated with SUDs, specifically alcohol use disorder, and serve as a possible biomarker for treating these common disorders.

机译：物质使用障碍（SUDS）对社会产生毁灭性的影响，并对医疗保健系统造成沉重的负担。鉴于酒精，烟草和大麻使用具有最高的普遍性，进一步了解这些泡沫的潜在病理生理学是至关重要的。脑电图是一种廉价，时间上优越的和可转换的技术，其能够通过评估各种与事件相关的潜在组件（包括不匹配的消极性）（MMN）进行调查。本综述的目标是探讨急性和慢性酒精，烟草和大麻在非患者群体中对MMN的影响和合并症精神病患者的影响。使用数据库PubMed进行文献搜索，36篇文章符合我们的包含和排除标准。我们发现，在急性和慢性酒精中的酒精中毒患者中，MMN振幅的衰减模式，这种诱饵不可遗传。报告有限，结果对急性和慢性烟草和大麻在MMN的影响混合。关于合并泡沫和精神病的报告甚至更少，也呈现了混合调查结果。这些初步结果表明MMN缺陷可能与泡沫，特别是酒精使用障碍有关，并用作治疗这些常见疾病的可能生物标志物。

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来源
《Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS)》 |2018年第4期|共12页
作者
Ramlakhan Jessica U.; Zomorrodi Reza; Downar Jonathan; Blumberger Daniel M.; Daskalakis Zafiris J.; George Tony P.; Kiang Michael; Barr Mera S.;
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Ctr Addict &

Mental Hlth Div Mood &

Anxiety Temerty Ctr Therapeut Brain Intervent 1001 Queen St;

Ctr Addict &

Mental Hlth Div Mood &

Anxiety Temerty Ctr Therapeut Brain Intervent 1001 Queen St;

Univ Hlth Network Krembil Res Inst Toronto ON Canada;

Ctr Addict &

Mental Hlth Div Mood &

Anxiety Temerty Ctr Therapeut Brain Intervent 1001 Queen St;

Ctr Addict &

Mental Hlth Div Mood &

Anxiety Temerty Ctr Therapeut Brain Intervent 1001 Queen St;

Ctr Addict &

Mental Hlth Addit Div BACDRL Toronto ON Canada;

Ctr Addict &

Mental Hlth Div Mood &

Anxiety Temerty Ctr Therapeut Brain Intervent 1001 Queen St;

Ctr Addict &

Mental Hlth Div Mood &

Anxiety Temerty Ctr Therapeut Brain Intervent 1001 Queen St;

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正文语种 eng
中图分类神经病学与精神病学;
关键词
substance use disorder; mismatch negativity; event-related potential; biomarker; psychosis;

机译：物质使用障碍;不匹配的消极性;事件相关的潜力;生物标志物;精神病;

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专利

1. Using Mismatch Negativity to Investigate the Pathophysiology of Substance Use Disorders and Comorbid Psychosis [J] . Ramlakhan Jessica U., Zomorrodi Reza, Downar Jonathan, Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) . 2018,第4期

机译：使用不匹配的消极性来研究物质使用障碍和合并精神病症的病理生理学
2. Dose-response relationship between number of comorbid anxiety disorders in adolescent bipolar/unipolar disorders, and psychosis, suicidality, substance abuse and familiality. [J] . Dilsaver SC, Akiskal HS, Akiskal KK, Journal of affective disorders . 2006,第3期

机译：青少年双相/单相障碍合并症焦虑症的数量与精神病，自杀，药物滥用和家族性之间的剂量反应关系。
3. Impact of Long-acting Antipsychotics as Initial Treatment in First Episode Psychosis Populations with Substance Use Disorder Comorbidity [J] . Abdel-Baki Amal, Thibault Dominic, Medrano Sofia, Early intervention in psychiatry . 2018,第S1期

机译：长效抗精神病药作为初始治疗在第一发作精神病患者中的影响，具有物质使用障碍合并症
4. Collaborative phenotype inference from comorbid substance use disorders and genotypes [C] . Jin Lu, Jiangwen Sun, Xinyu Wang, IEEE International Conference on Bioinformatics and Biomedicine . 2017

机译：从共病物质使用障碍和基因型的合作表型推断
5. "Is there an Obsessive Psychosis ?" --- An exploration of phenomenology, comorbidity and treatment outcome of obsessive-compulsive disorder, and a study of prognostic significance of phenomenology. [D] . Mathew, Teslin Mol. 1997

机译：“有强迫症吗？” ---强迫症的现象学，合并症和治疗结果的探讨，以及对现象学的预后意义的研究。
6. Head-to-head comparison of 1-year aripiprazole long-acting injectable (LAI) versus paliperidone LAI in comorbid psychosis and substance use disorder: impact on clinical status substance craving and quality of life [O] . Ilaria Cuomo, Georgios D Kotzalidis, Simone de Persis, 2018

机译：一年期阿立哌唑长效注射剂（LAI）与帕潘立酮LAI在合并症精神病和药物滥用中的面对面比较：对临床状态药物渴望和生活质量的影响
7. Auditory Mismatch Negativity in Youth Affected by Autism Spectrum Disorder With and Without Attenuated Psychosis Syndrome [O] . Giorgio Di Lorenzo, Assia Riccioni, Michele Ribolsi, 2020

机译：受自闭症谱系障碍影响的青年中的听觉不匹配消极性，无减毒精神病综合征

Using Mismatch Negativity to Investigate the Pathophysiology of Substance Use Disorders and Comorbid Psychosis

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