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首页> 外文期刊>Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) >Status Epilepticus and Multiple Sclerosis: A Case Presentation and Literature Review
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Status Epilepticus and Multiple Sclerosis: A Case Presentation and Literature Review

机译：状态癫痫和多发性硬化症：案例介绍与文献综述

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Purpose . To search the literature for the frequency, pathogenesis, prognosis, and treatment of seizures and status epilepticus (SE) in patients with multiple sclerosis (MS). Methods . We report 2 patients with MS who presented with SE and review the literature. Results . Seizures and SE episodes worsened during MS relapses in the first patient. SE episodes and MS relapses significantly decreased after initiation of natalizumab treatment but she still had seizures and was taking 4 antiepileptic drugs (AEDs). The second patient had super refractory SE and was treated with AEDs and coma induction; SE was controlled in 1 week. Antibodies against glycine receptors were reported in her serum after her death. Conclusion . SE has been reported to remain refractory to conventional AEDs, and improve with treatment of MS relapse. Seizures often occur during MS relapses, and might be the presenting symptom of MS or the only symptom of a relapse. Patients with MS and epilepsy have been reported to have more severe MS disease courses. Seizures are refractory to treatment in patients with MS with chronic epilepsy; however, prognosis is quite good in patients experiencing provoked seizures during an MS relapse. Since some EEG findings may have prognostic value, their evaluation is invaluable for the determination of outcome. No treatment guidelines have been specified for patients with MS and SE. However, treatment with AEDs, ideally new-generation AEDs, and an MS treatment review with a new protocol will ensure a fast response to the improvement of SE.
机译：目的 。在多发性硬化症（MS）患者中搜索癫痫发作，预后，癫痫发作和状态癫痫病毒（SE）的文献。方法 。我们报告2名患有SE的MS患者并审查文献。结果 。在MS期间癫痫发作和SE剧集在第一患者中复发。在Natalizumab治疗开始后，SE发作和MS复发显着降低，但她仍有癫痫发作并服用4种抗癫痫药物（AED）。第二款患者具有超级难治性SE，并用AED和彗形诱导治疗; SE被控制在1周。在她死亡之后，在她的血清中报道了对甘氨酸受体的抗体。结论 。据报道，SE仍然对常规AED难以难治，并改善治疗MS复发。癫痫发作经常发生在MS复发期间，并且可能是母版的呈现症状或复发的唯一症状。据报道，患有MS和癫痫的患者具有更严重的MS疾病课程。癫痫发作是MS与慢性癫痫的患者的难治性;然而，在MS复发期间，在经过挑衅癫痫发作的患者中，预后非常好。由于一些EEG结果可能具有预后价值，因此他们的评估对于确定结果非常宝贵。没有针对MS和SE的患者指定治疗指南。然而，患有AED的治疗，理想的是新的AED，以及新协议的MS治疗审查将确保对改进SE的快速响应。

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