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首页> 外文期刊>Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) >Abnormal Frequency Mismatch Negativity in Early Psychosis Outpatient Subjects
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Abnormal Frequency Mismatch Negativity in Early Psychosis Outpatient Subjects

机译：早期精神病门诊科目中异常频率不匹配消极性

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摘要

Background. Abnormalities of mismatch negativity (MMN), an event-related potential, indexing preattentive mechanisms, are consistently reported in schizophrenia (SZ). MMN abnormalities elicited to different deviant types have been recently shown to distinguish among patients according to length of their illness as well as inpatient versus outpatient status, and to be modulated by premorbid IQ. The objective of this study was to evaluate the MMN elicited by both frequency and duration deviant stimuli in patients with early schizophrenia (EP) recruited from an outpatient clinic in Boston, Massachusetts. Methods. Twenty-two healthy controls (HC) and 22 age-, handedness-, and gender-matched EP were tested using a frequency and duration MMN paradigm. Clinical data were also collected. Results. Frequency MMN amplitude but not duration MMN was significantly reduced in EP relative to HC subjects (P = .015). Conclusions. These results indicate that in this sample of early psychosis outpatient group, reductions in frequency MMN but not in duration MMN index clinical status. The relationship between age at first hospitalization and MMN frequency and duration amplitude and latency indicates that neurodevelopmental stage, auditory function, and clinical status are tightly linked.
机译：背景。在精神分裂症（SZ）中，不匹配消极性（MMN），事件相关潜在的潜在索引机制的异常持续存在。最近出现了不同偏差类型的MMN异常，以根据其疾病的长度以及住院患者与门诊状态的长度来区分患者，并通过预血管智商调节。本研究的目的是评估通过在马萨诸塞州波士顿的门诊诊所招募的早期精神分裂症（EP）患者患者患者患者引发的MMN。方法。使用频率和持续时间MMN范例测试了二十两次健康对照（HC）和22岁的年龄，手段和性别匹配的EP。还收集了临床资料。结果。 EP相对于HC受试者，EP中的频率MMN振幅而不是持续时间MMN（P = .015）。结论。这些结果表明，在这种早期精神病门诊病的样本中，频率MMN的减少但不在持续时间MMN指数临床状态。第一次住院和MMN频率和持续时间和延迟的年龄之间的关系表明神经发育阶段，听觉功能和临床状态紧密相关。

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