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首页> 外文期刊>Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) >Serum Neurosteroid Levels Are Associated With Cortical Thickness in Individuals Diagnosed With Posttraumatic Stress Disorder and History of Mild Traumatic Brain Injury
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Serum Neurosteroid Levels Are Associated With Cortical Thickness in Individuals Diagnosed With Posttraumatic Stress Disorder and History of Mild Traumatic Brain Injury

机译：血清神经活体水平与诊断出患有错误胁迫障碍和轻度创伤性脑损伤史的个体的皮质厚度有关

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Posttraumatic stress disorder (PTSD) co-occurring with mild traumatic brain injury (mTBI) is common in veterans. Worse clinical outcome in those with PTSD has been associated with decreased serum neurosteroid levels. Furthermore, decreased cortical thickness has been associated with both PTSD and mTBI. However, it is not known whether decreased neurosteroids are associated with decreased cortical thickness in PTSD co-occurring with mTBI. This study included 141 individuals divided into the following groups: (a) mTBI group (n = 32 [10 female, 22 male] veterans with a history of mTBI); (b) PTSD + mTBI group (n = 41 [6 female, 35 male] veterans with current PTSD with a history of mTBI); and (c) control group (n = 68 [35 female, 33 male] control participants), which were acquired through the Injury and Traumatic Stress (INTRuST) Clinical Consortium. Subjects underwent clinical assessment, magnetic resonance imaging at 3 T, and serum neurosteroid quantifications of allopregnanolone (ALLO) and pregnenolone (PREGN). Group differences in cortical thickness and associations between serum neurosteroid levels and cortical thickness were investigated. Cortical thickness was decreased in the PTSD + mTBI group compared with the other groups. In the PTSD + mTBI group, decreased cortical thickness was also associated with lower serum ALLO (right superior frontal cortex) and lower serum PREGN (left middle temporal and right orbitofrontal cortex). Cortical thickness in the middle temporal and orbitofrontal cortex was associated with PTSD symptom severity. There were no significant associations between neurosteroids and cortical thickness in the mTBI or control groups. Decreased cortical thickness in individuals with PTSD + mTBI is associated with decreased serum neurosteroid levels and greater PTSD symptom severity. Causality is unclear. However, future studies might investigate whether treatment with neurosteroids could counteract stress-induced neural atrophy in PTSD + mTBI by potentially preserving cortical thickness.
机译：与轻度创伤性脑损伤（MTBI）共同发生的后特性应激障碍（PTSD）在退伍军人中是常见的。患有PTSD的临床结果更糟糕的是与血清神经硬化水平降低有关。此外，降低皮质厚度与PTSD和MTBI均相关。然而，尚不知道降低的神经激素是否与MTBI共同发生的PTSD中的皮质厚度降低有关。本研究包括141个个人分为以下组：（a）MTBI组（N = 32 [10名女性，22名男性]退伍军人，具有MTBI的历史）; （b）PTSD + MTBI集团（N = 41 [6名女性，35名男性]退伍军人，具有目前具有MTBI历史的PTSD）; （c）对照组（n = 68 [35例女性，33名男性]控制参与者）通过损伤和创伤应激（核心）临床联盟获得。受试者接受临床评估，磁共振成像3t，血清Neureosteroide allopregnolone（Allo）和妊娠蛋白（妊娠）。研究了研究皮质厚度和血清神经活体水平与皮质厚度之间的缔合物的差异。与其他基团相比，PTSD + MTBI组皮质厚度降低。在PTSD + MTBI组中，降低皮质厚度也与下血清Allo（右上额前皮质）和下血清妊娠（左中间时颞rontalcortex）有关。中间时颞和眶内皮质的皮质厚度与PTSD症状严重程度有关。在MTBI或对照组中神经硬化和皮质厚度之间没有显着的关联。具有PTSD + MTBI的个体中的皮质厚度下降与降低的血清神经硬化水平和更高的可行科目为症状严重程度有关。因果关系尚不清楚。然而，未来的研究可能会调查通过潜在保留皮质厚度，可以调查用神经活体的治疗是否可以通过可能保留皮质厚度来抵消PTSD + MTBI中的胁迫诱导的神经萎缩。

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