• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) >Resting State EEG Characteristics During Sedation With Midazolam or Propofol in Older Subjects
【24h】

Resting State EEG Characteristics During Sedation With Midazolam or Propofol in Older Subjects

机译：休息状态脑电图在镇静的龄或异丙酚镇静

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background. Despite widespread application, little is known about the neurophysiological effects of light sedation with midazolam or propofol, particularly in older subjects. The aim of this study was to assess the effects of light sedation with midazolam or propofol on a variety of EEG measures in older subjects. Methods. In patients (>= 60 years without neuropsychiatric disease such as delirium), 2 EEG recordings were performed, before and after administration of either midazolam (n = 22) or propofol (n = 26) to facilitate an endoscopic procedure. Power spectrum, functional connectivity, and network topology based on the minimum spanning tree (MST) were compared within subjects. Results. Midazolam and propofol administration resulted in Richmond Agitation and Sedation Scale levels between 0 and -4 and between -2 and -4, respectively. Both agents altered the power spectra with increased delta (0.5-4 Hz) and decreased alpha (8-13 Hz) power. Only propofol was found to significantly reduce functional connectivity. In the beta frequency band, the MST was more integrated during midazolam sedation. Propofol sedation resulted in a less integrated network in the alpha frequency band. Conclusion. Despite the different levels of light sedation with midazolam and propofol, similar changes in power were found. Functional connectivity and network topology showed differences between midazolam and propofol sedation. Future research should establish if these differences are caused by the different levels of sedation or the mechanism of action of these agents.
机译：背景。尽管普遍应用，但对咪达唑仑或异丙酚的光镇静的神经生理作用很少，特别是在较老的受试者中。本研究的目的是评估光镇静与咪达唑仑或异丙酚对老科的各种EEG措施的影响。方法。在患者（> = 60年没有神经精神疾病如谵妄）中，进行2个EEG记录，在咪达唑仑（n = 22）或异丙酚（n = 26）的施用之前和之后进行，以促进内窥镜程序。在受试者中比较了基于最小生成树（MST）的功率谱，功能连接和网络拓扑。结果。咪达唑仑和异丙酚给药导致Richmond搅拌和镇静标度水平分别为0至-4和-2和-4之间。两种试剂改变了功率谱，增量增加（0.5-4Hz）和α（8-13Hz）功率降低。只发现异丙酚可显着降低功能性连接。在β频带中，MST在Midazolam镇静期间更集成。异丙酚镇静导致alpha频带中的集成网络较少。结论。尽管占咪达唑仑和异丙酚的光镇静水平不同，但发现了类似的权力变化。功能性连接和网络拓扑显示咪达唑仑和异丙酚镇静之间的差异。如果这些差异是由不同水平的镇静程度或这些药物的作用机制引起的，则应建立未来的研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号