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首页> 外文期刊>Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) >Resting EEG Measures of Brain Arousal in a Multisite Study of Major Depression
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Resting EEG Measures of Brain Arousal in a Multisite Study of Major Depression

机译：在大萧条的多立体研究中休息脑唤醒的脑电图措施

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Several studies have found upregulated brain arousal during 15-minute EEG recordings at rest in depressed patients. However, studies based on shorter EEG recording intervals are lacking. Here we aimed to compare measures of brain arousal obtained from 2-minute EEGs at rest under eyes-closed condition in depressed patients and healthy controls in a multisite project-Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care (EMBARC). We expected that depressed patients would show stable and elevated brain arousal relative to controls. Eighty-seven depressed patients and 36 healthy controls from four research sites in the United States were included in the analyses. The Vigilance Algorithm Leipzig (VIGALL) was used for the fully automatic classification of EEG-vigilance stages (indicating arousal states) of 1-second EEG segments; VIGALL-derived measures of brain arousal were calculated. We found that depressed patients scored higher on arousal stability (Z = -2.163, P = .015) and A stages (dominant alpha activity; P = .027) but lower on B1 stages (low-voltage non-alpha activity, P = .008) compared with healthy controls. No significant group differences were observed in Stage B2/3. In summary, we were able to demonstrate stable and elevated brain arousal during brief 2-minute recordings at rest in depressed patients. Results set the stage for examining the value of these measures for predicting clinical response to antidepressants in the entire EMBARC sample and evaluating whether an upregulated brain arousal is particularly characteristic for responders to antidepressants.
机译：在抑郁症患者的休息期间，几项研究发现了在15分钟的脑电图录音期间的上调脑唤醒。但是，缺乏基于较短EEG记录间隔的研究。在这里，我们旨在比较从抑郁症患者的抑郁症患者的患者和健康对照组的2分钟内闭梗塞的脑炎症措施，并在多站点项目建立主持人和临床护理（EMBARC）的抗抑郁症反应生物炎。我们预计抑郁症患者将显示稳定且脑升高的脑唤起相对于对照。在分析中，八十七名抑郁症患者和来自美国四个研究遗址的健康对照。警惕算法Leipzig（Vigall）用于全自动分类1秒EEG段的EEG-CALILANCE阶段（指示令人震惊状态）;计算了脑唤醒的Vigall衍生测量。我们发现抑郁症患者在唤醒稳定性（Z = -2.163，P = .015）和阶段（显性α活性; p = .027），但在B1阶段下降（低压非alpha活动，p = .008）与健康对照相比。在B2 / 3期间没有观察到明显的群体差异。总之，我们能够在抑郁症患者休息的短暂2分钟记录期间展示稳定和升高的脑震动。结果设定了检查这些措施的值的阶段，以预测整个Embarc样本中的抗抑郁药的临床反应，并评估是否是响应者对抗抑郁药的抗抑作用的特征。

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