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首页> 外文期刊>Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) >Evoked Potentials Investigations of Deficit Versus Nondeficit Schizophrenia: EEG-MEG Preliminary Data
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Evoked Potentials Investigations of Deficit Versus Nondeficit Schizophrenia: EEG-MEG Preliminary Data

机译：诱发的潜力调查缺陷与非近期精神分裂症：EEG-MEG初步数据

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Heterogeneity of schizophrenia is a major obstacle toward understanding the disorder. One likely subtype is the deficit syndrome (DS) where patients suffer from predominantly negative symptoms. This study investigated the evoked responses and the evoked magnetic fields to identify the neurophysiological deviations associated with the DS. Ten subjects were recruited for each group (Control, DS, and Nondeficit schizophrenia [NDS]). Subjects underwent magnetoencephalography (MEG) and electroencephalography (EEG) testing while listening to an oddball paradigm to generate the P300 as well as a paired click paradigm to generate the mid-latency auditory-evoked responses (MLAER) in a sensory gating paradigm. MEG-coherence source imaging (CSI) during P300 task revealed a significantly higher average coherence value in DS than NDS subjects in the gamma band (30-80 Hz), when listening to standard stimuli but only NDS subjects had a higher average coherence level in the gamma band than controls when listening to the novel sounds. P50, N100, and P3a ERP amplitudes (EEG analysis) were significantly decreased in NDS compared with DS subjects. The data suggest that the deviations in the 2 patient groups are qualitatively different. Deviances in NDS patients suggest difficulty in both early (as in the gating paradigm), as well as later top-down processes (P300 paradigm). The main deviation in the DS group was an exaggerated responsiveness to ongoing irrelevant stimuli detected by EEG whereas NDS subjects had an exaggerated response to novelty.
机译：精神分裂症的异质性是了解这种疾病的主要障碍。一个可能的亚型是患者患有主要症状的缺陷综合症（DS）。该研究研究了诱发的反应和诱发的磁场，以鉴定与DS相关的神经生理学偏差。为每组招募十个受试者（对照，DS和不良精神分裂症[NDS]）。受试者接受磁性脑图（MEG）和脑电图（EEG）测试，同时收听奇怪的范式以生成P300以及成对的单击范例，以在感官门控范例中生成中延迟听觉诱发的响应（MLAER）。 P300任务期间的MEG-相干源成像（CSI）在伽马带（30-80Hz）中显示出DS的显着更高的平均相干值（30-80 Hz），当时听到标准刺激，但只有NDS受试者的平均相干水平更高伽玛频带比聆听新的声音时控制。与DS受试者相比，NDS的P50，N100和P3A ERP幅度（EEG分析）显着降低。数据表明，2患者组中的偏差是定性不同的。 NDS患者的偏消在早期（如在Gating Paradigm）中遇到困难，以及以后的自上而下的过程（P300范例）。 DS组的主要偏差是对EEG检测到的持续无关刺激的夸大响应性，而NDS受试者对新奇的反应夸大了。

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