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首页> 外文期刊>Comparative Medicine >Intestinal Parasites and Anthelmintic Treatments in a Laboratory Colony of Wild-caught African Pouched Rats (Cricetomys ansorgei)
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Intestinal Parasites and Anthelmintic Treatments in a Laboratory Colony of Wild-caught African Pouched Rats (Cricetomys ansorgei)

机译：肠道寄生虫和野生捕获的非洲笨重的大鼠实验室殖民地（Cricetomys Ansorgei）中的寄生虫治疗

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摘要

African giant pouched rats (Cricetomys spp.) are large rodents native to subSaharan Africa. Wild-caught pouched rats identified as Cricetomys ansorgei (n = 49) were imported from Tanzania. A survey of gastrointestinal parasitism by fecal flotation revealed the presence of multiple parasites, including Nippostrongylus spp., Heterakis spp., Trichuris spp., Hymenolepis spp., Raillietina spp., and Eimeria spp. Oral self-administered fenbendazole (150 ppm), topical moxidectin (2 mg/kg), pyrantel pamoate (15 mg/kg), piperazine (100 mg/kg daily), and injectable ivermectin (0.25 mg/kg) were used to determine effective treatment options for the gastrointestinal parasites present in the colony. Pyrantel pamoate in a treat vehicle and piperazine in water bottles were easily administered and significantly reduced the numbers of animals shedding Nippostrongylus spp. and Heterakis spp. during the study. Moxidectin and ivermectin were clinically ineffective at reducing fecal egg shedding. Fenbendazole was most effective at clearing infection with Trichuris spp. Although 10 mg/kg praziquantel was ineffective, a single dose of 30 mg/kg praziquantel significantly reduced the number of African pouched rats that shed cestode embryos. A combination treatment may be necessary to successfully treat all parasites present in any given animal.
机译：非洲巨人笨拙的大鼠（Cricetomys SPP。）是天然的大啮齿动物。被鉴定为Cricetomys Ansorgei（n = 49）的野生捕获的笨重的大鼠从坦桑尼亚进口。对粪便浮选的胃肠寄生刺激症揭示了多种寄生虫的存在，包括Nippostrongylus SPP。，Heterachis SPP。，Trichuris SPP。，Hymenolepis SPP。，railieinolepis SPP。和Eimeria SPP。使用口服自我施用的芬苯唑（150ppm），局部次杀蛋白（2mg / kg），Pyrantel pamoate（15mg / kg），哌嗪（100mg / kg每日）和可注射的伊维菌素（0.25mg / kg）来确定殖民地存在的胃肠道寄生虫的有效治疗选择。 Pyrantel在治疗载体中的唾液酸盐和水瓶中的哌嗪易于施用，并且显着降低了脱磷尼三孢子SPP的动物数量。和heterachis spp。在研究期间。在减少粪便卵脱落时，莫克利霉菌和伊维菌素在临床上是无效的。 Fenbendazole最有效地用Trichuris SPP清除感染。虽然10mg / kg吡喹酮无效，但单剂量为30mg / kg吡喹酮，显着降低了脱落胚胎胚胎的非洲袋鼠大鼠的数量。可能需要组合治疗以成功治疗任何给定的动物中存在的所有寄生虫。

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