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Effects of Rodent Thermoregulation on Animal Models in the Research Environment

机译：啮齿动物热调节对研究环境中动物模型的影响

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摘要

To best promote animal wellbeing and the efficacy of biomedical models, scientific, husbandry, and veterinary professionals must consider the mechanisms, influences, and outcomes of rodent thermoregulation in contemporary research environments. Over the last 2 decades, numerous studies have shown that laboratory mice and rats prefer temperatures that are several degrees warmer than the environments in which they typically are housed within biomedical facilities. Physiologic changes to rodents that are cage-housed under standard temperatures (20 to 26 degrees C) are attributed to 'cold stress' and include alterations in metabolism, cardiovascular parameters, respiration, and immunologic function. This review article describes common behavioral and physiologic adaptations of laboratory mice and rats to cold stress within modern vivaria, with emphasis on environmental enrichment and effects of anesthesia and procedural support efforts. In addition, potential interventions and outcomes for rodents are presented, relative to the importance of repeating and reproducing experiments involving laboratory rodent research models of human disease.
机译：为了最佳促进动物福祉和生物医学模型，科学，畜牧业和兽医专业人员的疗效必须考虑当代研究环境中啮齿动物的啮齿动物温度调节的机制，影响和结果。在过去的2世纪数十年中，许多研究表明，实验室小鼠和大鼠更喜欢比通常在生物医学设施内的环境温暖的多度温暖的温度。在标准温度（20至26℃）下笼养的啮齿动物的生理变化归因于“冷应激”，包括代谢，心血管参数，呼吸和免疫功能的改变。该综述文章介绍了实验室小鼠和大鼠在现代vivaria内对冷应激的常见行为和生理调整，重点是环境富集和麻醉和程序支持努力的影响。此外，涉及啮齿动物的潜在干预和结果，相对于涉及人类疾病的实验室啮齿动物研究模型的重复和再现实验的重要性。

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