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The Influence of Pain and Analgesia in Rodent Models of Sepsis

机译：脓毒症啮齿动物模型中疼痛和镇痛的影响

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摘要

Sepsis is a multifaceted host response to infection that dramatically affects patient outcomes and the cost of health care. Animal models are necessary to replicate the complexity and heterogeneity of clinical sepsis. However, these models entail a high risk of pain and distress due to tissue trauma, inflammation, endotoxin-mediated hyperalgesia, and other mechanisms. Several recent studies and initiatives address the need to improve the welfare of animals through analgesics and standardize the models used in preclinical sepsis research. Ultimately, the goal is to provide high-fidelity, humane animal models that better replicate the clinical course of sepsis, to provide more effective translation and advance therapeutic discovery. The purpose of this review is to discuss the current understanding of the roles of pain and analgesia in rodent models of sepsis. The current definitions of sepsis along with an overview of pain in human sepsis are described. Finally, welfare concerns associated with animal models of sepsis and the most recent considerations for relief of pain and distress are reviewed.
机译：败血症是对感染的多方型宿主反应，从而大大影响患者结果和保健费用。动物模型对于复杂性和临床脓毒症的复杂性和异质性是必要的。然而，由于组织创伤，炎症，内毒素介导的痛觉过敏和其他机制，这些模型需要很高的疼痛和痛苦。最近的几项研究和举措解决了通过镇痛药改善动物福利，并标准化临床前脓毒症研究中使用的模型。最终，目标是提供高保真，人性化动物模型，更好地复制败血症的临床进程，提供更有效的翻译和提前治疗发现。本综述的目的是讨论目前对败血症啮齿动物模型中疼痛和镇痛的作用的理解。描述了败血症的目前的定义以及人类盲肠疼痛的概述。最后，综述了与败血症动物模型相关的福利问题以及最近的痛苦痛苦和痛苦的考虑。

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