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首页> 外文期刊>Comparative Medicine >Interacting Influences of Sleep, Pain, and Analgesic Medications on Sleep Studies in Rodents
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Interacting Influences of Sleep, Pain, and Analgesic Medications on Sleep Studies in Rodents

机译：睡眠，疼痛和镇痛药物对啮齿动物睡眠研究的影响

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摘要

This overview provides a brief summary of the complex interactions that link sleep, pain, and analgesic medications. Sleep scientists and clinicians are well aware of these relationships and understand that maintaining healthy pain-free subjects in a stable environment is essential to generating interpretable data and valid conclusions. However, these concepts and the data that support bidirectional interactions between sleep and pain may be less known to those who are not sleep scientists yet need such information to protect and advance both animal wellbeing and research validity (for example, veterinarians, IACUC members). Abundant human evidence supports the disruptive effect of pain and the modulatory effects of analgesic drugs on sleep; however, analgesic drugs can alter both sleep and the electroencephalogram, which is the primary objective measure for identifying sleep and evaluating sleep properties in both humans and animals. Consideration of the modulatory and interactive relationships of sleep, pain, and analgesic medications is essential to designing and conducting valid and reproducible sleep research using animal subjects.
机译：此概述提供了链接睡眠，疼痛和镇痛药的复杂相互作用的简要概述。睡眠科学家和临床医生很清楚这些关系，并了解在稳定的环境中保持健康的无痛主体对于产生可解释的数据和有效的结论至关重要。然而，这些概念和支持睡眠与疼痛之间双向相互作用的数据可能会对那些不是睡眠科学家的人来说越少，但需要这些信息来保护和推进动物福祉和研究有效性（例如，兽医，IACUC成员）。丰富的人类证据支持疼痛的破坏性效果和镇痛药在睡眠中的调节作用;然而，镇痛药可以改变睡眠和脑电图，这是识别睡眠和评估人类和动物的睡眠性质的主要目标措施。思考睡眠，疼痛和镇痛药物的调节和互动关系对于使用动物受试者设计和进行有效和可重复的睡眠研究至关重要。

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